Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile
R. de Groot, M. M. van Loenen, A. Guislain, B. P. Nicolet, J. J. Freen-van Heeren, O. Verhagen, M. M. van den Heuvel, J. de Jong, P. Burger, E. van der Schoot, R. M. Spaapen, D. Amsen, J. B. Haanen, K. Monkhorst, K. J. Hartemink, M. C. Wolkers
The paper isolates and expands tumor-reactive T cells from NSCLC tumors, finding that polyfunctional T cells correlate with immune-engaged T cell profiles and tumor reactivity.
bioRxiv · Jun 8, 2019Immunology