Author

K. J. Hartemink

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

A. Guislain· 2 shared K. Monkhorst· 2 shared M. C. Wolkers· 2 shared R. de Groot· 2 shared A. A. F. A. Veenhof· 1 shared A. F. M. Dost· 1 shared A. Sexton-Oates· 1 shared A.-M. Dingemans· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

A. Guislain

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Druggable Growth Dependencies and Tumor Evolution Analysis in Patient-Derived Organoids of Neuroendocrine Cancer

T. L. Dayton, N. Alcala, L. Moonen, L. den Hartigh, L. Mangiante, L. Lap, A. F. M. Dost, J. Beumer, S. Levy, R. S. van Leeuwaarde, W. M. Hackeng, K. Samsom, C. Voegele, A. Sexton-Oates, H. Begthel, , H. Clevers

This study establishes patient-derived tumor organoids (PDTOs) for neuroendocrine cancers, identifies therapeutic vulnerabilities, and highlights EGF dependency in pulmonary neuroendocrine tumors.

bioRxiv · Oct 31, 2022Cancer Biology

Effective generation of tumor-infiltrating lymphocyte products from metastatic non-small-cell lung cancer (NSCLC) lesions irrespective of location and previous treatments.

S. M. Castenmiller, R. de Groot, A. Guislain, K. Monkhorst, K. J. Hartemink, A. A. F. A. Veenhof, E. F. Smit, J. B. A. G. Haanen, M. C. Wolkers

This study shows that tumor-infiltrating lymphocytes (TILs) can be effectively generated from metastatic NSCLC lesions regardless of location or prior treatments, with 76% showing anti-tumoral activity.

bioRxiv · Jan 28, 2022Cancer Biology

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

R. de Groot, M. M. van Loenen, A. Guislain, B. P. Nicolet, J. J. Freen-van Heeren, O. Verhagen, M. M. van den Heuvel, J. de Jong, P. Burger, E. van der Schoot, R. M. Spaapen, D. Amsen, J. B. Haanen, K. Monkhorst, K. J. Hartemink, M. C. Wolkers

The paper isolates and expands tumor-reactive T cells from NSCLC tumors, finding that polyfunctional T cells correlate with immune-engaged T cell profiles and tumor reactivity.

bioRxiv · Jun 8, 2019Immunology