The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8+ T cell responses
Anthony T. Phan, Emily Aunins, Elisa Cruz-Morales, Garima Dwivedi, Molly E. Bunkofske, Julia N. Eberhard, Daniel L. Aldridge, Hooda Said, Omar Banda, Ying K. Tam, David A. Christian, Robert H. Vonderheide, Ross M. Kedl, Drew Weissman, Mohamad‐Gabriel Alameh, Christopher A. Hunter
This study shows that IL-27, induced by mRNA-LNP vaccines, enhances CD8+ T cell responses through type I IFN signaling, improving vaccine efficacy against pathogens and tumors.
bioRxiv · Jan 16, 2025 · PreprintImmunology