Author

W. J. Janssen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Campos Codo· 1 shared A. Getahun· 1 shared A. Q. Harder· 1 shared A. Sackhiem· 1 shared A. van Bokhoven· 1 shared B. A. Bouchard· 1 shared B. Crute· 1 shared B. Gao· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperImmunology

A. Campos Codo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells.

W. H. Palmer, L. A. Leaton, A. Campos Codo, P. S. Hume, B. Crute, M. Stone, A. van Bokhoven, R. P. Tobin, M. McCarter, W. J. Janssen, J. Roest, S. Zhu, J. Petersen, J. P. Vivian, J. Rossjohn, , P. J. Norman

This study identifies KIR3DL3 expression in T cells, showing it is upregulated by unconventional stimulation and varies by individual genetic variants.

bioRxiv · Aug 17, 2022Immunology

Single cell RNA Sequencing Identifies G-protein Coupled Receptor 87 as a Novel Basal Cell Marker of Distal Honeycomb Cysts in Idiopathic Pulmonary Fibrosis

K. Heinzelmann, Q. Hu, Y. Hu, E. Dobrinskikh, H. M. Ulke, M. Ansari, C. Leavitt, C. Mirita, T. Trudeau, M. L. Saal, P. Rice, B. Gao, W. J. Janssen, I. V. Yang, H. B. Schiller, , M. Königshoff

The paper identifies GPR87 as a novel marker for KRT5+ basal cells in IPF distal bronchioles and honeycomb cysts using single-cell RNA sequencing.

bioRxiv · Sep 3, 2021Cell Biology

Increased Histone-DNA Complexes and Endothelial-Dependent Thrombin Generation in Severe COVID-19

B. A. Bouchard, C. Colovos, M. Lawson, A. Sackhiem, K. J. Mould, W. J. Janssen, M. J. Cohen, D. Majumdar, K. Freeman

This study finds elevated histone-DNA complexes and altered thrombin generation in severe COVID-19 patients, with endothelial-dependent thrombin generation contributing to coagulopathy.

bioRxiv · Jul 3, 2021Biochemistry

Targeting of the NLRP3 Inflammasome for early COVID-19

C. Marchetti, K. Mould, I. W. Tengesdal, W. J. Janssen, C. A. Dinarello

This study identifies early NLRP3 inflammasome activation in COVID-19 patients, linking it to cytokine release syndrome and suggesting NLRP3 as a therapeutic target.

bioRxiv · Feb 24, 2021 · PreprintImmunology

Disulfide disruption reverses mucus dysfunction in allergic airway disease

L. E. Morgan, S. K. Shenoy, D. Raclawska, N. A. Emezienna, V. L. Richardson, N. Hara, A. Q. Harder, H. M. El-Batal, C. M. Magin, D. E. G. Villalon, G. Duncan, J. S. Hanes, J. S. Suk, D. J. Thornton, F. Holguin, , C. M. Evans

This study shows that reducing disulfide bonds in mucins reverses mucus dysfunction in asthma by improving mucociliary clearance and reducing airway hyperreactivity.

bioRxiv · Sep 14, 2019Physiology