Author

P. K. Buehler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Gomez-Mejia· 2 shared A. S. Zinkernagel· 2 shared C. Acevedo· 2 shared C. Vulin· 2 shared C.-C. Chang· 2 shared M. Huemer· 2 shared R. A. Schuepbach· 2 shared S. D. Brugger· 2 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

A. Gomez-Mejia

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Neutrophil and monocyte dysfunctional effector response towards bacterial challenge in critically-ill COVID-19 patients

S. Mairpady Shambat, A. Gomez-Mejia, T. A. Schweizer, M. Huemer, C.-C. Chang, C. Acevedo, J. Bergada Pijuan, C. Vulin, N. Miroshnikova, D. A. Hofmanner, P. D. Wendel Garcia, M. P. Hilty, P. K. Buehler, R. A. Schuepbach, S. D. Brugger, A. S. Zinkernagel

This study shows that severe hypercytokinemia in COVID-19 patients impairs neutrophil and monocyte function against bacterial challenges, leading to reduced microbicidal capacity and altered receptor signaling.

PLOS Pathogens · Jan 10, 2022Peer-reviewedImmunology

Blunted Fas signaling favors RIPK1-driven neutrophil necroptosis in critically ill COVID-19 patients

T. A. Schweizer, S. Mairpady Shambat, C. Vulin, S. Hoeller, C. Acevedo, M. Huemer, A. Gomez-Mejia, C.-C. Chang, J. Baum, S. Hertegonne, E. Hitz, D. A. Hofmaenner, P. K. Buehler, H. Moch, R. A. Schuepbach, , A. S. Zinkernagel

The paper shows that in critically ill COVID-19 patients, dysregulated Fas signaling leads to increased RIPK1-driven necroptosis in neutrophils, contributing to disease severity.

bioRxiv · Mar 19, 2021 · PreprintImmunology