Author

V. M. Shoba

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Choudhary· 3 shared A. Deb· 2 shared A. Sadagopan· 2 shared S. K. Chaudhary· 2 shared B. L. Ebert· 1 shared D. N. P. M. Godage· 1 shared D. R. Liu· 1 shared E. S. Fischer· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBiochemistry

A. Choudhary

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Author profile →

3 papers

Recent·Most cited

Bifunctional small molecules that induce nuclearlocalization and targeted transcriptional regulation

W. J. Gibson, A. Sadagopan, V. M. Shoba, A. Choudhary, M. L. Meyerson, S. L. Schreiber

This paper develops bifunctional molecules that induce nuclear localization and transcriptional regulation, showing their potential for therapeutic applications in cancer.

bioRxiv · Jul 7, 2023Biochemistry

Development and applications of chimera platforms for tyrosine phosphorylation

R. Pergu, V. M. Shoba, S. K. Chaudhary, D. N. P. M. Godage, A. Deb, S. Singha, U. Dhawa, V. Anokhina, S. Singh, S. U. Siriwardena, A. Choudhary

This paper develops two platforms to create chimeric small molecules that induce tyrosine phosphorylation, demonstrating their ability to trigger phosphorylation and biological activities in target proteins.

bioRxiv · Mar 5, 2023Biochemistry

Proteolysis Targeting Chimeras With Reduced Off-targets

T. M. Nguyen, V. Sreekanth, A. Deb, P. Kokkonda, P. K. Tiwari, K. A. Donovan, V. M. Shoba, S. K. Chaudhary, J. A. M. Mercer, S. Lai, A. Sadagopan, M. Jan, E. S. Fischer, D. R. Liu, B. L. Ebert, A. Choudhary

This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.

bioRxiv · Nov 18, 2021Pharmacology & Toxicology