R. Ravindran

Peroxisome biogenesis initiated by protein phase separation

This study shows that Pex13 and Pex5 undergo liquid-liquid phase separation to form transient transport channels for cargo into peroxisomes.

Therapeutic reversal of prenatal pontine ID1 signaling in DIPG

This study identifies ID1 upregulation in DIPG tumor cells and shows that CBD can reduce ID1-driven invasiveness in vitro and in vivo.

IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease

Endosomes facilitate mitochondrial clearance by enhancing Parkin recruitment to mitochondria

This study shows endosomes facilitate Parkin recruitment to mitochondria, a key step in mitophagy, by interacting with CARP2 before Parkin.

Therapeutic efficacy of an immune stimulatory gene therapy strategy in a mouse model of high grade brainstem glioma

This paper tests an immune-stimulatory gene therapy in a mouse model of DIPG, showing increased survival and anti-tumor immunity through adenoviral delivery of TK and Flt3L.

Paradigm of Vanadium pentoxide nanoparticle-induced autophagy and apoptosis in triple-negative breast cancer cells

This study investigates vanadium pentoxide nanoparticles' effects on triple-negative breast cancer cells, showing time-dependent antioxidant/pro-oxidant properties, lysosomal/mitochondrial accumulation, autophagy induction, and apoptosis, with no observed toxicity in mice.

Patterns of recurrence after curative-intent surgery for pancreas cancer reinforce the importance of locoregional control and adjuvant chemotherapy.

This study examines recurrence patterns in pancreas cancer patients after surgery, finding that locoregional recurrence is common and linked to R+ resection and venous invasion, with adjuvant chemotherapy improving survival.