Author

P. M. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Apffel· 2 shared A. S. Flozak· 2 shared A. Yemelyanov· 2 shared C. J. Gottardi· 2 shared C. J. Wu· 2 shared G. Oliveira· 2 shared H. Keshishian· 2 shared J. M. Quinn· 2 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Apffel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

Y. J. Wang, A. Yemelyanov, C. D. Go, S. Kim, J. M. Quinn, A. S. Flozak, P. M. Le, S. Liang, A.-C. Gingras, M. Ikura, N. Ishiyama, C. J. Gottardi

This study identifies α-catenin mechanosensitivity as a driver of cytokinesis failure through sequestration of LZTS2, linking it to polyploidization and retinal dystrophy.

Journal of Cell Biology · Jan 9, 2025Peer-reviewedCell Biology

α-catenin middle- and actin-binding domain unfolding mutants differentially impact epithelial strength and sheet migration

J. M. Quinn, Y. Wang, M. N. Wood, A. S. Flozak, P. M. Le, A. Yemelyanov, P. W. Oakes, C. J. Gottardi

This study compares how mutations in α-catenin's M-domain and FABD affect epithelial strength and migration by analyzing cell behavior and protein interactions.

bioRxiv · Feb 1, 2023Cell Biology

Optimized liquid and gas phase fractionation increase HLA-peptidome coverage for primary cell and tissue samples

S. Klaeger, A. Apffel, K. R. Clauser, S. Sarkizova, G. Oliveira, S. Rachimi, P. M. Le, A. Tarren, V. Chea, J. G. Abelin, D. A. Braun, P. A. Ott, H. Keshishian, N. Hacohen, D. Keskin, , S. A. Carr

The paper improves HLA-peptidome coverage using optimized liquid and gas phase fractionation methods, enabling detection of more peptides from limited clinical tissue samples.

bioRxiv · May 25, 2021Biochemistry

Thousands of novel unannotated proteins expand the MHC I immunopeptidome in cancer

T. Ouspenskaia, T. Law, K. R. Clauser, S. Klaeger, S. Sarkizova, F. Aguet, B. Li, E. Christian, B. A. Knisbacher, P. M. Le, C. R. Hartigan, H. Keshishian, A. Apffel, G. Oliveira, W. Zhang, , A. Regev

The paper identifies thousands of novel unannotated proteins in cancer that contribute to the MHC I immunopeptidome, expanding potential targets for immunotherapy.

bioRxiv · Feb 12, 2020 · PreprintCancer Biology