Author

S. Klaeger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. R. Clauser· 5 shared S. A. Carr· 5 shared J. G. Abelin· 3 shared N. Hacohen· 3 shared S. Sarkizova· 3 shared A. Apffel· 2 shared C. J. Wu· 2 shared D. B. Keskin· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersImmunology

K. R. Clauser

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Author profile →

5 papers

Recent·Most cited

Sensitive, high-throughput HLA-I and HLA-II immunopeptidomics using parallel accumulation-serial fragmentation mass spectrometry

K. Phulphagar, C. Ctortecka, S. Vaca, S. Klaeger, E. K. Verzani, G. M. Hernandez, N. Udeshi, K. R. Clauser, J. Abelin, S. A. Carr

This paper develops a high-throughput, sensitive MS-based immunopeptidomics workflow to identify HLA-I and HLA-II peptides from tumor samples, achieving improved coverage with reduced sample requirements.

bioRxiv · Mar 10, 2023Immunology

MONTE enables serial immunopeptidome, ubiquitylome, proteome, phosphoproteome, acetylome analyses of sample-limited tissues

J. G. Abelin, E. J. Bergstrom, H. B. Taylor, K. D. Rivera, S. Klaeger, C. Xu, C. J. White, M. E. Olive, M. Maynard, M. H. Kane, S. Rachimi, D. R. Mani, M. A. Gillette, K. R. Clauser, N. D. Udeshi, S. A. Carr

MONTE enables serial multi-omic analysis of immunopeptidome, ubiquitylome, proteome, phosphoproteome, and acetylome from the same tissue samples, preserving precious human material and identifying immunotherapeutic targets.

bioRxiv · Jun 22, 2021 · PreprintCancer Biology

Optimized liquid and gas phase fractionation increase HLA-peptidome coverage for primary cell and tissue samples

S. Klaeger, A. Apffel, K. R. Clauser, S. Sarkizova, G. Oliveira, S. Rachimi, P. M. Le, A. Tarren, V. Chea, J. G. Abelin, D. A. Braun, P. A. Ott, H. Keshishian, N. Hacohen, D. Keskin, , S. A. Carr

The paper improves HLA-peptidome coverage using optimized liquid and gas phase fractionation methods, enabling detection of more peptides from limited clinical tissue samples.

bioRxiv · May 25, 2021Biochemistry

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs

S. Weingarten-Gabbay, S. Klaeger, S. Sarkizova, L. R. Pearlman, D.-Y. Chen, M. R. Bauer, H. B. Taylor, H. L. Conway, C. H. Tomkins-Tinch, Y. Finkel, A. Nachshon, M. Gentili, K. D. Rivera, D. B. Keskin, C. M. Rice, , P. C. Sabeti

The paper identifies HLA-I peptides from SARS-CoV-2 in infected cells, revealing epitopes from both canonical and out-of-frame ORFs, which could inform vaccine development.

bioRxiv · Oct 2, 2020 · PreprintImmunology

Thousands of novel unannotated proteins expand the MHC I immunopeptidome in cancer

T. Ouspenskaia, T. Law, K. R. Clauser, S. Klaeger, S. Sarkizova, F. Aguet, B. Li, E. Christian, B. A. Knisbacher, P. M. Le, C. R. Hartigan, H. Keshishian, A. Apffel, G. Oliveira, W. Zhang, , A. Regev

The paper identifies thousands of novel unannotated proteins in cancer that contribute to the MHC I immunopeptidome, expanding potential targets for immunotherapy.

bioRxiv · Feb 12, 2020 · PreprintCancer Biology