A. S. Flozak

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

This study identifies α-catenin mechanosensitivity as a driver of cytokinesis failure through sequestration of LZTS2, linking it to polyploidization and retinal dystrophy.

α-catenin middle- and actin-binding domain unfolding mutants differentially impact epithelial strength and sheet migration

This study compares how mutations in α-catenin's M-domain and FABD affect epithelial strength and migration by analyzing cell behavior and protein interactions.

Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions

The paper identifies alpha-T-catenin expression in Schwann cell adherens junctions of peripheral nerves and links CTNNA3 to neuroglial functions, potentially explaining its association with non-cardiac diseases.

Lung injury induces alveolar type 2 cell hypertrophy and polyploidy with implications for repair and regeneration

This study shows lung injury induces alveolar type 2 cell hypertrophy and polyploidy, which can be reduced by inhibiting the integrated stress response.

Hypercapnia limits β-catenin mediated alveolar type 2 cell progenitor function by altering Wnt production from adjacent fibroblasts

This study shows hypercapnia inhibits β-catenin signaling in alveolar type 2 cells by altering Wnt production from fibroblasts, impairing lung repair after injury.

Single-cell RNA-seq reveals spatially restricted multicellular fibrotic niches during lung fibrosis

The paper identifies monocyte-derived alveolar macrophages as causally linked to fibrosis in lung tissue through autocrine signaling and fibroblast activation.