P. Mlcochova

CD4 T cell contact drives macrophage cell cycle progression and susceptibility to lentiviral transduction

The paper shows that CD4 T cell contact induces macrophage cell cycle progression from G0 to G1, increasing their susceptibility to lentiviral transduction.

Hypoxia drives HIF2-dependent macrophage cell cycle entry and susceptibility to lentiviral transduction

This study shows hypoxia induces HIF2-dependent cell cycle entry in macrophages, leading to increased susceptibility to lentiviral transduction and is observed in tumor-associated macrophages.

Cell cycle independent role of cyclin D3 in host restriction of SARS-CoV-2 infection

This study shows that cyclin D3 depletion during SARS-CoV-2 infection enhances virus titres and is independent of cell cycle arrest, suggesting a role in restricting viral assembly.

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

SARS-CoV-2 B.1.617.2 Delta variant replication, sensitivity to neutralising antibodies and vaccine breakthrough

This study evaluates the replication, antibody sensitivity, and vaccine efficacy of the SARS-CoV-2 B.1.617.2 Delta variant compared to other variants and vaccine-elicited immunity.

Extended in vitro inactivation of SARS-CoV-2 by titanium dioxide surface coating

This study demonstrates that titanium dioxide-coated surfaces can inactivate SARS-CoV-2 under ambient light within 5 hours of exposure.

In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix

The paper identifies a novel protease inhibitor resistance signature in HIV-1 matrix through genotypic and phenotypic analysis of patients failing PI therapy.

IFN-independent cell cycle arrest and SAMHD1 activation following TLR4 activation in macrophages

This study shows TLR4 activation in macrophages induces G0 arrest and SAMHD1 activation independently of IFN, blocking HIV-1 infection through SAMHD1.