T. Golub

FDX1 regulates cellular protein lipoylation through direct binding to LIAS.

This study identifies FDX1 as a direct regulator of protein lipoylation by binding to LIAS, essential for cell survival under low glucose conditions.

DNA-based copy number analysis confirms genomic evolution of PDX models

The paper reassesses genomic evolution in PDX models using DNA-based copy number profiles, finding significant genomic divergence between primary tumors and PDXs across passages.

Gene expression has more power for predicting in vitro cancer cell vulnerabilities than genomics

This study compares DNA- and expression-based models for predicting cancer cell viability and finds expression models are more accurate and interpretable.

The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research

The paper describes the Angiosarcoma Project, a patient-partnered initiative that generates genomic data on angiosarcoma, identifying recurrent mutations and potential therapeutic targets.

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

The paper identifies WRN helicase as a synthetic lethal target in microsatellite unstable cancers through CRISPR/Cas9 and RNAi screens, showing its essentiality in MSI cell lines.