Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst
Claire S. Simon, Afshan McCarthy, Laura M. Woods, Desislava P. Staneva, Martin Proks, Nazmus Salehin, Georgia Lea, Qiulin Huang, Madeleine Linneberg-Agerholm, Alex Faulkner, Athanasios Papathanasiou, Kay T. Elder, Phil Snell, Leila Christie, Patricia Garcia, , Kathy K. Niakan
The paper shows that inhibiting ERK signaling expands epiblast cells capable of becoming naive pluripotent stem cells in humans, while FGF stimulation expands hypoblast markers.
Nature Communications · Jul 28, 2025Peer-reviewedDevelopmental Biology