Inducible and reversible inhibition of miRNA-mediated gene repression in vivo
Gaspare La Rocca, Bryan King, Bing Shui, Xiaoyi Li, Minsi Zhang, Kemal Marc Akat, Paul Ogrodowski, Chiara Mastroleo, Kevin Chen, Vincenzo Cavalieri, Yilun Ma, Viviana Anelli, Doron Betel, Joana Alves Vidigal, Thomas Tuschl, , Andrea Ventura
This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.
eLife · Aug 31, 2021Peer-reviewedMolecular Biology