Author

Prachi Khare

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Benjamin J. PolaccoiD· 3 shared Jiewei XuiD· 3 shared Nevan J. KroganiD· 3 shared Ruth HüttenhainiD· 3 shared Manon EckhardtiD· 2 shared Mark von ZastrowiD· 2 shared Qiongyu LiiD· 2 shared Rasika S. VartakiD· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersSystems Biology

Benjamin J. PolaccoORCID

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3 papers

Recent·Most cited

A proximity proteomics pipeline with improved reproducibility and throughput

Xiaofang Zhong, Qiongyu Li, Benjamin J. Polacco, Trupti Patil, Aaron Marley, Helene Foussard, Prachi Khare, Rasika S. Vartak, Jiewei Xu, Jeffrey F. DiBerto, Bryan L. Roth, Manon Eckhardt, Mark von Zastrow, Nevan J. Krogan, Ruth Hüttenhain

This paper introduces a scalable proximity proteomics pipeline that improves reproducibility and throughput in biotinylation-based spatial proteomics.

Molecular Systems Biology · Jul 1, 2024Peer-reviewedSystems Biology

A foundational atlas of autism protein interactions reveals molecular convergence

Belinda Wang, Rasika S. Vartak, Yefim Zaltsman, Zun Zar Chi Naing, Kelsey M. Hennick, Benjamin J. Polacco, Ali Bashir, Manon Eckhardt, Mehdi Bouhaddou, Jiewei Xu, Nawei Sun, Micaela C. Lasser, Yuan M. Zhou, Justin McKetney, Keelan Z. Guiley, , Nevan J. Krogan

The paper constructs a PPI network of 100 high-confidence ASD genes, identifies novel interactions, and uses AlphaFold-Multimer to prioritize variants for functional validation in organoids.

bioRxiv · Dec 3, 2023 · PreprintSystems Biology

Profiling the proximal proteome of the mu opioid receptor identifies novel regulators of receptor signaling and trafficking

Benjamin J. Polacco, Braden T. Lobingier, Emily E. Blythe, Nohely Abreu, Prachi Khare, Matthew K. Howard, Alberto J. Gonzalez-Hernandez, Jiewei Xu, Qiongyu Li, Brandon Novy, Zun Zar Chi Naing, Brian K. Shoichet, Willow Coyote‐Maestas, Joshua Levitz, Nevan J. Krogan, , Ruth Hüttenhain

The paper identifies novel regulators of mu opioid receptor signaling and trafficking using proximity labeling and proteomics.

bioRxiv · Mar 28, 2022 · PreprintSystems Biology