The paper constructs a PPI network of 100 high-confidence ASD genes, identifies novel interactions, and uses AlphaFold-Multimer to prioritize variants for functional validation in organoids.

bioRxiv · Dec 3, 2023 · PreprintSystems Biology

Profiling the proximal proteome of the mu opioid receptor identifies novel regulators of receptor signaling and trafficking

Benjamin J. Polacco, Braden T. Lobingier, Emily E. Blythe, Nohely Abreu, Prachi Khare, Matthew K. Howard, Alberto J. Gonzalez-Hernandez, Jiewei Xu, Qiongyu Li, Brandon Novy, Zun Zar Chi Naing, Brian K. Shoichet, Willow Coyote‐Maestas, Joshua Levitz, Nevan J. Krogan, , Ruth Hüttenhain

The paper identifies novel regulators of mu opioid receptor signaling and trafficking using proximity labeling and proteomics.

bioRxiv · Mar 28, 2022 · PreprintSystems Biology

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David Ezra Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, Alicia Richards, Beril Tutuncuoglu, , Natalia Jura

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.

Nature · Apr 30, 2020Peer-reviewedSystems Biology✦ In-depth digest

Integrative genomics analysis identifies ACVR1B as a candidate causal gene of emphysema distribution in non-alpha 1-antitrypsin deficient smokers

Adel R. Boueiz, Robert Chase, Andrew E. Lamb, Sool Lee, Zun Zar Chi Naing, Michael H. Cho, Margaret M. Parker, Craig P. Hersh, James D. Crapo, Andrew B. Stergachis, Ruth Tal‐Singer, Dawn Lisa DeMeo, Edwin K. Silverman, Peter J. Castaldi, for the COPDGene investigators

The paper identifies ACVR1B as a candidate causal gene for emphysema distribution by integrating GWAS, eQTL, and epigenomic data.

bioRxiv · Sep 22, 2017 · PreprintGenomics