Author

Helene Foussard

Gladstone InstitutesORCID 0000-0002-5063-113XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Systems Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:proteomics· 4 Approach:experimental assay· 3 Organism:human· 3 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Benjamin J. PolaccoiD· 4 shared Manon EckhardtiD· 4 shared Danielle L. SwaneyiD· 3 shared Jiewei XuiD· 3 shared Jyoti BatraiD· 3 shared Kirsten ObernieriD· 3 shared Kliment A. VerbaiD· 3 shared Lisa MioriniD· 3 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersSystems Biology

Benjamin J. PolaccoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

Jyoti Batra, Magdalena Rutkowska, Yuan Zhou, Chengjin Ye, Rithika Adavikolanu, Janet M. Young, Durga Anand, Sooraj Verma, Haripriya Parthasarathy, Martin Gordon, Shivali Malpotra, Anastasija Čupić, Thomas Kehrer, Mélanie Dos Santos, Ronald Benjamin, , Nevan J. Krogan

Cell Host & Microbe · May 14, 2026Peer-reviewedSystems Biology

A proximity proteomics pipeline with improved reproducibility and throughput

Xiaofang Zhong, Qiongyu Li, Benjamin J. Polacco, Trupti Patil, Aaron Marley, Helene Foussard, Prachi Khare, Rasika S. Vartak, Jiewei Xu, Jeffrey F. DiBerto, Bryan L. Roth, Manon Eckhardt, Mark von Zastrow, Nevan J. Krogan, Ruth Hüttenhain

This paper introduces a scalable proximity proteomics pipeline that improves reproducibility and throughput in biotinylation-based spatial proteomics.

Molecular Systems Biology · Jul 1, 2024Peer-reviewedSystems Biology

Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories

Mehdi Bouhaddou, Ann‐Kathrin Reuschl, Benjamin J. Polacco, Lucy Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn Μ. Jang, Jiewei Xu, Jack M. Moen, Alicia Richards, Yuan M. Zhou, Bhavya Harjai, , Nevan J. Krogan

The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.

bioRxiv · Oct 19, 2022 · PreprintSystems Biology

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David Ezra Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, Alicia Richards, Beril Tutuncuoglu, , Natalia Jura

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.

Nature · Apr 30, 2020Peer-reviewedSystems Biology✦ In-depth digest