The glycine locating at random coil of picornaviruses VP3 enhances viral pathogenicity by targeting p53 to promote apoptosis and autophagy
R. Mao, F. Yang, D. Sun…·h. zheng
This study shows that the Gly129 residue in FMDV-VP3 enhances viral pathogenicity by promoting apoptosis and autophagy through p53 interaction, and this residue is conserved across picornaviruses.