Author

J. H. Costa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Microbiology· 5

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3

Frequent Co-Authors

B. Arnholdt-Schmitt· 5 shared C. Noceda· 4 shared S. Aziz· 4 shared T. P. Fill· 3 shared A. Adhloeya· 2 shared A. Kumari· 2 shared A. Rokas· 2 shared B. Revuru· 2 shared

Activity by Year

2020-2022 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersCell Biology

B. Arnholdt-Schmitt

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10 papers

Recent·Most cited

Allelic gene polymorphisms suspected to diversify the individual early metabolic response upon influenza H3N2 and SARS-CoV-2 infections

B. Arnholdt-Schmitt, S. Aziz, J. H. Costa

The paper identifies time-dependent transcript levels of polymorphic ASMTL genes in human nasal epithelial cells during influenza H3N2 and SARS-CoV-2 infections, suggesting potential allelic targets for early metabolic response prediction.

bioRxiv · May 5, 2022Cell Biology

Major complex trait for early de novo programming 'CoV-MAC-TED' detected in human nasal epithelial cells infected by two SARS-CoV-2 variants is promising for designing therapeutic strategies

J. H. Costa, S. Aziz, B. Arnholdt-Schmitt, C. Noceda

The paper identifies CoV-MAC-TED as a key metabolic trait in SARS-CoV-2 infected nasal epithelial cells and shows its relevance for anti-viral strategy development.

bioRxiv · Oct 19, 2021Cell Biology

Transcriptome data from human nasal epithelial cells infected by H3N2 influenza virus indicate early unbalanced ROS/RNA levels, temporarily increased aerobic fermentation linked to enhanced α-tubulin and rapid energy-dependent IRF9-marked immunization

J. H. Costa, S. Aziz, B. Arnholdt-Schmitt, C. Noceda

The paper examines transcriptome changes in human nasal epithelial cells infected with H3N2 influenza virus, identifying early ROS/RNS imbalance, increased glycolysis, and α-tubulin expression linked to energy-dependent immunization.

bioRxiv · Oct 18, 2021 · PreprintCell Biology

Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin

A. C. Colabardini, F. Wang, Z. Dong, L. Pardeshi, M. C. Rocha, J. H. Costa, T. F. dos Reis, A. Brown, Q. Z. Jaber, M. Fridman, T. Fill, A. Rokas, I. Malavazi, K. H. Wong, G. H. Goldman

This study investigates transcriptional heterogeneity in Aspergillus fumigatus strains responding to caspofungin, identifying a core response and variable response linked to secondary metabolite biosynthesis and iron homeostasis.

bioRxiv · Jul 15, 2021Microbiology

Aspergillus fumigatus acetate utilisation impacts virulence traits and pathogenicity

L. N. Ries, P. A. de Castro, L. P. Silva, C. Valero, T. F. dos Reis, R. Saborano, I. F. Duarte, G. F. Persinoti, J. L. Steenwyk, A. Rokas, F. Almeida, J. H. Costa, T. P. Fill, S. Sze Wah Wong, V. Aimanianda, , G. H. Goldman

This paper investigates how acetate utilization by Aspergillus fumigatus affects virulence traits and pathogenicity, showing its role in secondary metabolite secretion, cell wall composition, and in vivo virulence.

bioRxiv · Jun 9, 2021 · PreprintMicrobiology

Adaptive reprogramming during early seed germination requires temporarily enhanced fermentation a critical role for alternative oxidase (AOX) regulation that concerns also microbiota effectiveness

B. Revuru, C. Noceda, M. Gunasekharan, S. R. Kumar, K. L. L. Thiers, J. H. Costa, E. S. Macedo, A. Kumari, K. J. Gupta, S. Srivatsava, A. Adhloeya, M. Oliveira, I. Velada, D. Sircar, R. Sathishkumar, B. Arnholdt-Schmitt

The paper investigates the role of alternative oxidase (AOX) and sucrose in early seed germination, showing that AOX regulation and microbial interactions are critical for metabolic adjustment and germination efficiency.

bioRxiv · Jun 8, 2021Cell Biology

ROS/RNS balancing, aerobic fermentation regulation and cell cycle control a complex early trait ('CoV-MAC-TED') for combating SARS-CoV-2-induced cell reprogramming

J. H. Costa, G. Mohanapriya, B. Revuru, C. Noceda, K. L. L. Thiers, S. Aziz, S. Srivatsava, M. Oliveira, K. J. Gupta, A. Kumari, D. Sircar, S. R. Kumar, A. Achra, R. Sathishkumar, A. Adhloeya, B. Arnholdt-Schmitt

The paper identifies a complex trait, CoV-MAC-TED, linked to SARS-CoV-2-induced cell reprogramming through unbalanced ROS/RNS levels and aerobic fermentation.

bioRxiv · Jun 8, 2021Cell Biology

Small molecule analysis of extracellular vesicles produced by Cryptococcus gattii: identification of a tripeptide controlling cryptococcal infection in an invertebrate host model

F. Reis, J. H. Costa, L. Honorato, L. Nimrichter, T. Pacheco Fill, M. Rodrigues

This study identifies a tripeptide in Cryptococcus gattii extracellular vesicles that enhances survival in an invertebrate infection model.

bioRxiv · Jan 18, 2021Microbiology

Phytotoxic tryptoquialanines produced in vivo by Penicillium digitatum are exported in extracellular vesicles

J. H. Costa, J. M. Bazioli, L. D. Barbosa, P. L. T. dos Santos Junior, F. Reis, T. Klimeck, C. M. Crnkovic, R. G. S. Berlinck, A. Sussulini, M. L. Rodrigues, T. P. Fill

This study shows that Penicillium digitatum exports tryptoquialanine A, a phytotoxic alkaloid, in extracellular vesicles during citrus infection, inhibiting seed germination and causing tissue damage.

bioRxiv · Dec 3, 2020Microbiology

The histone deacetylase clr3regulates secondary metabolite production and growth under oxidative stress conditions in Penicillium brasilianum

D. Y. Akiyama, M. C. Rocha, J. H. Costa, I. Malavazi, T. P. Fill

This study shows that deletion of the histone deacetylase gene clr3 in Penicillium brasilianum reduces growth under oxidative stress and secondary metabolite production.

bioRxiv · May 1, 2020 · PreprintMicrobiology