Author

R. A. Scolyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:clustering· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

J. S. Wilmott· 5 shared G. V. Long· 4 shared J. F. Thompson· 2 shared A. A. Jungbluth· 1 shared A. Andea· 1 shared A. Baggiolini· 1 shared A. C. Monovich· 1 shared A. H. Guo· 1 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersCancer Biology

J. S. Wilmott

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5 papers

Recent·Most cited

Anatomic position determines oncogenic specificity in melanoma

J. M. Weiss, M. V. Hunter, N. M. Cruz, A. Baggiolini, M. Tagore, Y. Ma, S. Misale, M. Marasco, T. Simon-Vermot, N. R. Campbell, F. Newell, J. S. Wilmott, P. A. Johansson, J. F. Thompson, G. V. Long, , R. M. White

The paper shows that anatomic position influences oncogenic specificity in melanoma by identifying position-specific gene programs that interact with oncogenes like CRKL.

bioRxiv · Nov 14, 2020Cancer Biology

The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics

W. Giblin, L. Bringman-Rodenbarger, A. H. Guo, S. Kumar, A. C. Monovich, A. M. Mostafa, M. E. Skinner, M. Azar, A. S. A. Mady, C. H. Chung, N. Kadambi, K.-A. Melong, H.-J. Lee, L. Zhang, P. Sajjakulnukit, , D. B. Lombard

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

bioRxiv · Sep 7, 2020 · PreprintCancer Biology

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

S. Z. Wu, D. L. Roden, G. Al-Eryani, N. Bartonicek, K. Harvey, A. S. Cazet, C.-L. Chan, S. Junankar, M. N. Hui, E. Millar, J. Beretov, L. Horvath, A. M. Joshua, P. Stricker, J. S. Wilmott, , A. Swarbrick

This study shows that cryopreservation of human cancers preserves tumour heterogeneity for single-cell multi-omics analysis, with comparable results to fresh tissue.

bioRxiv · Jun 4, 2020Cancer Biology

Temporal and spatial modulation of the immune response of the murine Gl261 glioma tumor microenvironment

K. J. McKelvey, A. L. Hudson, R. Prasanna Kumar, J. S. Wilmott, G. H. Attrill, G. V. Long, R. A. Scolyer, S. J. Clarke, H. R. Wheeler, C. I. Diakos, V. M. Howell

The paper characterizes temporal and spatial immune changes in a murine glioma model, showing increased tumor proliferation and vascularization correlate with shifts in immune cell populations and cytokine levels.

bioRxiv · Nov 28, 2019Cancer Biology

Epigenetic Profiling for the Molecular Classification of Metastatic Brain Tumors

J. I. J. Orozco, T. A. Knijnenburg, A. O. Manughian-Peter, M. P. Salomon, G. Barkhoudarian, J. R. Jalas, J. S. Wilmott, P. Hothi, X. Wang, Y. Takasumi, M. E. Buckland, J. F. Thompson, G. V. Long, C. S. Cobbs, I. Shmulevich, , D. M. Marzese

This study develops a DNA methylation-based classifier, BrainMETH, to categorize brain metastases by tissue origin and therapeutic subtypes using epigenetic profiling.

bioRxiv · Feb 22, 2018Cancer Biology