Author

R. Agrawal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

A. Singh· 2 shared J. Lammerding· 2 shared J. Nandakumar· 2 shared V. K. Pal· 2 shared A. Chenine· 1 shared A. Diehl· 1 shared A. Vyakarnam· 1 shared B. Subhadra· 1 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMicrobiology

A. Singh

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The Lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding

M. Wallace, G. R. Fedorchak, R. Agrawal, R. M. Gilbert, J. Patel, S. Park, M. Paszek, J. Lammerding

This study shows that the Lamin A/C Ig-fold undergoes cell density-dependent conformational changes that affect antibody binding, without altering protein levels or nuclear mechanics.

bioRxiv · Nov 22, 2022Cell Biology

The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor

R. Agrawal, J. P. Gillies, J. L. Zang, J. Zhang, S. R. Garrott, H. Shibuya, J. Nandakumar, M. E. DeSantis

The paper identifies KASH5 as a dynein activating adaptor essential for meiotic chromosomal movements, showing it binds dynein and enables processive motility.

bioRxiv · Mar 11, 2022Cell Biology

Significant Broad Spectrum Antiviral activity of Bi121 Against Different Variants of SARS-CoV-2

B. Subhadra, R. Agrawal, V. K. Pal, A. Chenine, J. G. Mattathil, A. Singh

This study evaluates Bi121's antiviral activity against multiple SARS-CoV-2 variants using pseudotyped viruses and cell-based assays, showing broad-spectrum efficacy.

bioRxiv · Jan 29, 2022 · PreprintMicrobiology

Allosteric Regulation of Human Plastins

C. Schwebach, E. Kudryashova, R. Agrawal, W. Zheng, E. H. Egelman, D. S. KUDRYASHOV

This study investigates how allosteric regulation between actin-binding domains of plastins modulates actin bundling and cross-linking.

bioRxiv · Dec 1, 2021 · PreprintBiochemistry

Confined migration induces heterochromatin formation and alters chromatin accessibility

C.-R. Hsia, J. McAllister, O. Hasan, J. Judd, S. Lee, R. Agrawal, C.-Y. Chang, P. Soloway, J. Lammerding

The paper shows that confined cell migration induces heterochromatin formation and alters chromatin accessibility, which affects migration speed and cellular functions.

bioRxiv · Sep 22, 2021Cell Biology

Single residue substitution in protamine 1 disrupts sperm genome packaging and embryonic development in mice

L. Moritz, S. Schon, M. Rabbani, Y. Sheng, D. Pendlebury, R. Agrawal, C. Sultan, K. Jorgensen, X. Zheng, A. Diehl, K. Ragunathan, Y.-C. Hu, J. Nandakumar, J. Li, K. Orwig, , S. Hammoud

This study shows that a single amino acid substitution in mouse protamine 1 disrupts DNA packaging and causes infertility by altering protein function and developmental outcomes.

bioRxiv · Sep 16, 2021 · PreprintBiochemistry

Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

V. K. Pal, R. Agrawal, S. Rakshit, P. Shekar, D. T. N. Murthy, A. Vyakarnam, A. Singh

This paper shows that hydrogen sulfide (H2S) prevents HIV rebound by maintaining mitochondrial function and redox balance, and that H2S donors can suppress viral reactivation in ART-suppressed individuals.

bioRxiv · Apr 21, 2021Microbiology

Structural insights into unique features of the human mitochondrial ribosome recycling

R. Koripella, M. Sharma, P. Risteff, P. Keshavan, R. Agrawal

The paper presents a cryo-EM structure of the human mitoribosome-RRFmt complex, revealing unique structural features and interactions involved in mitoribosome recycling.

bioRxiv · Aug 24, 2018Biophysics