D. G. Lalloo

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: results of preclinical efficacy testing

This study evaluates two antivenoms as alternatives to SAIMR Polyvalent in Eswatini, finding they are equally or more effective against the most common snake venom but less effective against others.

Flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria

This paper develops a flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria, showing it can detect cell aggregates and reveal subpopulation dynamics not captured by traditional CFU counting.

Both the inflammatory response and clinical outcome differ markedly between adults with pneumococcal and meningococcal meningitis in a high HIV-1 prevalent setting in sub-Saharan Africa

This study compares inflammatory responses and clinical outcomes between pneumococcal and meningococcal meningitis in HIV-high prevalence settings, finding worse outcomes in pneumococcal cases.

Impact of efavirenz, ritonavir-boosted lopinavir and nevirapine based antiretroviral regimens on the pharmacokinetics of lumefantrine and safety of artemether-lumefantrine in falciparum-negative HIV-infected Malawian adults stabilized on antiretroviral therapy

This study evaluates how different antiretroviral therapies affect lumefantrine pharmacokinetics and the safety of artemether-lumefantrine in HIV-infected adults, finding significant variations in lumefantrine exposure and safety profiles.