Author

R. Barrangou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:mechanistic / dynamical model· 1 Assay:metabolomics· 1

Frequent Co-Authors

C. M. Theriot· 2 shared A. D. Reed· 1 shared A. Gulati· 1 shared A. K. Stewart· 1 shared A. Lahiri· 1 shared A. Stewart· 1 shared B. A. Adler· 1 shared B. F. Cress· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

C. M. Theriot

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genome-wide Characterization of Diverse Bacteriophages Enabled by RNA-Binding CRISPRi

B. A. Adler, M. J. Al-Shimary, J. R. Patel, E. Ambruster, D. Colognori, E. J. Charles, K. V. Miller, A. Lahiri, M. Trinidad, R. Boger, J. Nomburg, S. Beurnier, M. L. Cui, R. Barrangou, V. K. Mutalik, , B. F. Cress

The paper develops a CRISPRi-ART system to knock down protein expression in diverse bacteriophages and identifies essential genes, including many with unknown functions.

bioRxiv · Sep 18, 2023 · PreprintMicrobiology

Distinct bile salt hydrolase substrate preferences dictate C. difficile pathogenesis

M. H. Foley, M. E. Walker, A. K. Stewart, S. O'Flaherty, E. C. Gentry, G. Allen, S. Patel, M. Pan, V. V. Beaty, M. E. Vanhoy, M. K. Dougherty, S. K. McGill, A. Gulati, P. Dorrestein, E. S. Baker, , C. M. Theriot

The paper identifies bile salt hydrolase (BSH) substrate preferences and shows they inhibit C. difficile by altering bile acid pools in CDI models.

bioRxiv · Mar 24, 2022 · PreprintMicrobiology

Strain-dependent inhibition of Clostridioides difficile by commensal Clostridia encoding the bile acid inducible (bai) operon

A. D. Reed, M. A. Nethery, A. Stewart, R. Barrangou, C. M. Theriot

This study shows that commensal Clostridia with the bai operon inhibit C. difficile growth in a strain-dependent manner through bile acid conversion, but C. difficile outcompetes them in co-culture.

bioRxiv · Jan 22, 2020Microbiology

Immune Loss as a Driver of Coexistence During Host-Phage Coevolution

J. L. Weissman, R. Holmes, R. Barrangou, S. Moineau, W. F. Fagan, B. R. Levin, P. L. Johnson

The paper shows that immune loss in bacteria can lead to stable coexistence with phages, contrasting with fitness tradeoffs, through theoretical and experimental analysis of CRISPR-Cas systems.

bioRxiv · Sep 18, 2017Ecology