R. Fischer

The paper maps interactions of ER ubiquitin ligases and identifies a complex involving RNF26 that modulates innate immune signaling via the cGAS-STING pathway.

This study identifies and validates lipocalin 2 (LCN2) as a sensitive and specific biomarker for bacterial meningitis in cerebrospinal fluid.

This study shows that inhibiting BMP-signalling in Drosophila secondary cells alters seminal proteome composition and ejaculate function, revealing cross-talk between secretory cell types.

The paper shows ejaculate performance declines with male age in Drosophila due to sperm and seminal protein deterioration, but this decline can be ameliorated by targeting insulin-like peptide-producing cells.

The paper identifies synaptic ectosomes released by helper T cells that contain TCR and CD40L, enabling dendritic cell maturation and cytokine production.

This study identifies ataxin-3 as a mediator of NOD2 and TLR2 signaling in myeloid cells, linking innate immune sensing to metabolic processes and mitochondrial function.

This study identifies RASSF1A as a regulator of nuclear actin levels by supporting exportin-6 binding to RAN GTPase, linking it to tumor suppression through MRTF/SRF regulation.

This paper shows SPRTN protease and CHK1 form a cross-activation loop to protect DNA replication from stress by regulating CHK1 chromatin eviction and DPC removal.

This paper introduces a method combining instant structured illumination microscopy with TIRF to achieve higher resolution and faster imaging of live samples near the coverslip.