M. Holbrook

Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera

The paper uses hamster sera to map antigenic differences among SARS-CoV-2 variants, showing JN.1 has significant antigenic divergence from XBB.1.5.

Comparative aerosol and surface stability of SARS-CoV-2 Variants of Concern

This study compares aerosol and surface stability of SARS-CoV-2 variants, finding early VOCs more stable than WA1, but Delta and Omicron do not show increased stability, suggesting stability changes are not the main driver of transmissibility.

Severe acute respiratory disease in American mink (Neovison vison) experimentally infected with SARS-CoV-2

This study shows that SARS-CoV-2 infected mink develop severe respiratory disease with features similar to severe acute respiratory disease in humans.

UV-C light completely blocks highly contagious Delta SARS-CoV-2 aerosol transmission in hamsters

This study shows UV-C light prevents airborne SARS-CoV-2 transmission between hamsters.

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

This study shows that the B.1.427/1.429 (epsilon) SARS-CoV-2 variants cause more severe disease and higher viral loads in the upper respiratory tract in Syrian hamsters compared to the ancestral B.1 (614G) strain.

Increased aerosol transmission for B.1.1.7 (alpha variant) over lineage A variant of SARS-CoV-2

This study shows that the B.1.1.7 variant of SARS-CoV-2 is more efficiently transmitted via aerosols than lineage A in Syrian hamsters.

Immunogenicity of low dose prime-boost vaccination of mRNA vaccine CV07050101 in non-human primates

This study evaluates the immunogenicity of a low-dose prime-boost mRNA vaccine in non-human primates, finding limited antibody and T cell responses in some animals.

Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques

This study compares the pathogenicity of SARS-CoV-2 variants B.1.1.7 and B.1.351 in rhesus macaques, finding differences in clinical outcomes and immune responses.

Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

This study identifies ultrapotent bispecific antibodies that neutralize emerging SARS-CoV-2 variants by targeting multiple spike protein regions, showing efficacy in vitro and in a hamster model.

ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 1 disease

This study shows that the ChAdOx1 nCoV-19 vaccine protects Syrian hamsters from SARS-CoV-2 B.1.1.7 and B.1.351 variants, preventing weight loss, lung lesions, and viral replication.

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques

This study shows intranasal ChAdOx1 nCoV-19 vaccination reduces SARS-CoV-2 shedding in animal models but not pneumonia protection.

SARS-CoV-2 disease severity and transmission efficiency is increased for airborne but not fomite exposure in Syrian hamsters

This study shows that airborne SARS-CoV-2 exposure causes more severe disease and efficient transmission in Syrian hamsters compared to fomite exposure.

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

Repurposing Pyramax for the Treatment of Ebola Virus Disease: Additivity of the Lysosomotropic Pyronaridine and Non-Lysosomotropic Artesunate

The paper evaluates the antiviral efficacy of Pyramax(R), a malaria treatment, against Ebola virus and finds its components act additively to inhibit infection.

Pyronaridine Tetraphosphate Efficacy Against Ebola Virus Infection in Guinea Pig

This paper evaluates pyronaridine tetraphosphate's efficacy against Ebola and Marburg viruses in guinea pigs, showing 40% survival and suggesting its potential for antiviral repurposing.

Photon-counting cine-cardiac CT in the mouse

This paper demonstrates 4D photon-counting detector CT in a mouse atherosclerosis model, achieving high-fidelity spectral and material information with reduced noise and improved resolution.