Author

R. J. Seeley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 5

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. B. Klein· 2 shared A. M. Fritzen· 2 shared C. Clemmensen· 2 shared J. Lund· 2 shared K. Karstoft· 2 shared M. Kleinert· 2 shared T. S. Nicolaisen· 2 shared A. B. Watters· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersPhysiology

A. B. Klein

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Liver Fibroblast Growth Factor 21 (FGF21) is Required for the Full Anorectic Effect of the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide in Male Mice fed High Carbohydrate Diets

T. D. V. Le, P. Fathi, A. B. Watters, B. J. Ellis, N. Bozadjieva-Kramer, M. B. Perez, A. I. Sullivan, J. P. Rose, L. L. Baggio, J. Koehler, J. L. Brown, M. B. Bales, K. G. Nwaba, J. E. Campbell, D. J. Drucker, , J. E. Ayala

This study shows that FGF21 is necessary for liraglutide's full weight loss effect in male mice on high-carbohydrate diets, mediated through neuronal pathways.

bioRxiv · Jan 3, 2023 · PreprintPhysiology

The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance

A. B. Klein, T. S. Nicolaisen, K. Johann, A. M. Fritzen, C. V. Mathiesen, C. Gil, N. S. Pilmark, K. Karstoft, M. B. Blond, J. S. Quist, R. J. Seeley, K. Faerch, J. Lund, M. Kleinert, C. Clemmensen

This study shows metformin increases GDF15 but does not rely on the GDF15-GFRAL pathway for its weight-lowering effects in mice.

bioRxiv · Feb 16, 2022Physiology

Vertical Sleeve Gastrectomy Induces Enteroendocrine Cell Differentiation of Intestinal Stem Cells Through Farnesoid X Receptor Activation

K.-S. Kim, B. C. E. Peck, Y.-H. Hung, K. L. Koch-Laskowski, L. Wood, P. H. Dedhia, J. R. Spence, R. J. Seeley, P. Sethupathy, D. A. Sandoval

This study shows vertical sleeve gastrectomy increases enteroendocrine cells via FXR activation in intestinal stem cells, using RNAseq and organoid experiments.

bioRxiv · Apr 22, 2021 · PreprintPhysiology

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

A. B. Klein, T. S. Nicolaisen, N. Ortenblad, K. D. Gejl, R. Jensen, A. M. Fritzen, E. L. Larsen, K. Karstoft, H. E. Poulsen, T. Morville, R. E. Sahl, J. W. Helge, J. Lund, S. Falk, M. Lyngbaek, , C. Clemmensen

The paper shows that exercise increases circulating GDF15 levels, but this physiological increase does not suppress appetite or exercise motivation like pharmacological GDF15.

bioRxiv · Oct 23, 2020Physiology

In vivo imaging of individual islets across the mouse pancreas reveals a heterogeneous insulin secretion response to glucose

H. Frikke-Schmidt, P. Arvan, R. J. Seeley, C. Cras-Meneur

The paper uses in vivo imaging to study insulin secretion from individual pancreatic islets in mice, finding that their responses to glucose are heterogeneous in vivo, unlike in culture.

bioRxiv · May 22, 2020Physiology