R. J. Sullivan

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product

This study uses high-throughput microfluidic technology to enrich CTCs from large blood volumes, enabling detailed molecular and morphological analysis of tumor cells in metastatic cancer patients.

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor

This study identifies immune cell types and biomarkers in irMyocarditis using single-cell RNA sequencing and TCR analysis across heart, blood, and tumor tissues.

Structural and functional vascular dysfunction within brain metastases is linked to pembrolizumab inefficacy

This study links structural and functional vascular dysfunction in brain metastases to pembrolizumab resistance by analyzing perfusion MRI data from 44 patients.

Plasma proteomic biomarkers identify non-responders and reveal biological insights about the tumor microenvironment in melanoma patients after PD1 blockade

The paper identifies plasma proteomic biomarkers that predict non-response to PD1 blockade in melanoma patients and links them to tumor microenvironment biology.

Microenvironmental correlates of immune checkpoint inhibitor response in human melanoma brain metastases revealed by T cell receptor and single-cell RNA sequencing

Plasma-derived exosomal analysis and deconvolution enables prediction and tracking of melanoma checkpoint blockade response

This paper uses plasma-derived exosomal RNA to predict and track melanoma response to immune checkpoint inhibitors by analyzing tumor and immune signatures.