Author

R. Koechl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

D. Hayward· 2 shared J. Biggs O'May· 2 shared L. de Boer· 2 shared L. Vanes· 2 shared V. Tybulewicz· 2 shared A. Griffiths· 1 shared A. Guni· 1 shared A. Jandke· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

D. Hayward

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses

J. Biggs O'May, L. Vanes, L. de Boer, H. Hartweger, S. Kunzelmann, D. Hayward, M. Llorian, D. A. Lewis, R. Koechl, V. Tybulewicz

This study shows that WNK1-dependent water influx is essential for CD4+ T cell proliferation and T cell-dependent antibody responses.

bioRxiv · Mar 16, 2022Immunology

T cell migration requires ion and water influx to regulate actin polymerization

L. de Boer, L. Vanes, S. Melgrati, J. Biggs O'May, D. Hayward, P. Driscoll, J. Day, A. Griffiths, R. Magueta, A. Morrell, J. I. MacRae, R. Koechl, V. Tybulewicz

This study shows that chemokine-induced T cell migration requires water entry at the leading edge to facilitate actin polymerization.

bioRxiv · Mar 16, 2022Immunology

Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration.

A.-L. Law, S. Jalal, T. Pallett, F. Mosis, A. Guni, S. Brayford, L. Yolland, S. Marcotti, J. Levitt, S. Poland, M. Rowe-Sampson, A. Jandke, R. Koechl, G. Pula, S. M. Ameer-Beg, , M. Krause

This study identifies NHSL1 as a negative regulator of Scar/WAVE-Arp2/3 activity, inhibiting lamellipodia stability and cell migration.

bioRxiv · May 11, 2020Cell Biology