K. Mitra

Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma

This study shows that mitochondrial-containing sEVs from MDRCs activate and polarize Th17 and Th2 cells in asthma, contributing to airway inflammation.

SLC12A9 is a lysosome-detoxifying ammonium - chloride co-transporter

This study identifies SLC12A9 as a lysosomal ammonium exporter that maintains lysosomal homeostasis by transporting ammonium and chloride.

Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA

This study shows that Msi2 induces cardiac hypertrophy and heart failure by causing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA.

Fine-tuned repression of Drp1 driven mitochondrial fission primes a slow cycling stem/progenitor-like state towards accelerating neoplastic transformation of keratinocytes

The paper shows that fine-tuned Drp1 repression primes keratinocytes for neoplastic transformation by maintaining a stem/progenitor-like state with elevated stem markers and Cyclin E.

Mito-SinCe2 Approach to Quantify Relationships between Mitochondrial Dynamics and Energetics status

The paper develops and validates mito-SinCe2, an approach to quantify the relationship between mitochondrial dynamics and energetics, revealing distinct states and linear relationships in ovarian tumor initiating cells.

S-MiRAGE: A quantitative, secreted RNA-based reporter of gene expression and cell persistence

S-MiRAGE uses secreted RNA to quantitatively track cell persistence and gene expression in vitro and in vivo.