Author

R. M. Guerra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Organism:yeast· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. J. Pagliarini· 4 shared J. J. Coon· 2 shared K. A. Overmyer· 2 shared A. Burgardt· 1 shared A. D. Patterson· 1 shared A. K. Bartlett· 1 shared A. Parolia· 1 shared A. S. Frost· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersBiochemistry

D. J. Pagliarini

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

B. Chen, D. C. Stark, P. V. Jadhav, T. M. Lynn-Nguyen, B. S. Halligan, N. J. Rossiter, N. Sindoni, M. Shin, J. A. Paulo, M. Chang, I. Koo, S. Koshkin, S. Eyunni, P. Ronchi, M. T. Paulsen, , Y. M. Shah

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

bioRxiv · Feb 2, 2024 · PreprintCell Biology

COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells

L. Pelosi, L. Morbiato, A. Burgardt, F. Tonello, A. K. Bartlett, R. M. Guerra, K. K. Ferizhendi, M. A. Desbats, B. Rascalou, M. Marchi, L. Vazquez-Fonseca, C. Agosto, G. Zanotti, M. Roger-Margueritat, M. Alcazar-Fabra, , F. Pierrel

This study identifies COQ4 as catalyzing the oxidative decarboxylation of the C1 carbon in CoQ biosynthesis in eukaryotic cells.

bioRxiv · Nov 13, 2023Biochemistry

Hem25p is a mitochondrial IPP transporter

J. Tai, R. M. Guerra, S. W. Rogers, Z. Fang, L. K. Muehlbauer, E. Shishkova, K. A. Overmyer, J. J. Coon, D. J. Pagliarini

The paper identifies Hem25p as a mitochondrial IPP transporter in yeast, essential for CoQ biosynthesis.

bioRxiv · Mar 14, 2023 · PreprintBiochemistry

Aim18p and Aim46p are CHI-domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.

J. M. Schmitz, J. F. Wolters, N. H. Murray, R. M. Guerra, C. A. Bingman, C. T. Hittinger, D. J. Pagliarini

The paper identifies Aim18p and Aim46p as mitochondrial hemoproteins in yeast with structural similarities to CHI proteins but distinct functional roles.

bioRxiv · Nov 15, 2022 · PreprintBiochemistry

Structure and functionality of a multimeric human COQ7:COQ9 complex

M. Manicki, H. Aydin, L. A. Abriata, K. A. Overmyer, R. M. Guerra, J. J. Coon, M. Dal Peraro, A. S. Frost, D. J. Pagliarini

The paper presents the structure and functional analysis of a multimeric COQ7:COQ9 complex involved in CoQ biosynthesis, revealing its mechanism for accessing hydrophobic precursors and coordinating CoQ synthesis.

Molecular Cell · Nov 1, 2022Peer-reviewedBiochemistry