R. Nguyen

Volumetric Compression Shifts Rho GTPase Balance and Induces Mechanobiological Cell State Transition

The paper investigates how volumetric compression affects Rho GTPase balance and mechanobiological cell state transitions through physical and molecular changes.

A "cooperative collaboration" between HAND2 and MYCN shapes neuroblastoma cell identity

This study identifies a cooperative interaction between HAND2 and MYCN in neuroblastoma that regulates enhancer binding and gene transcription, and shows that targeting these factors suppresses tumor growth.

In vivo correction of cystic fibrosis mediated by PNA nanoparticles

This study demonstrates systemic gene editing using PNA nanoparticles to correct the F508del CFTR mutation in mice, showing partial CFTR function restoration and tissue-specific correction without off-target effects.

Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.