Author

Z. K. Tuong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Research Focus:differential expression· 6 Assay:bulk RNA-seq· 5 Research Focus:cell-cell communication· 4 Assay:scRNA-seq· 4 Assay:spatial transcriptomics· 4

Frequent Co-Authors

M. R. Clatworthy· 7 shared M. Haniffa· 4 shared C. Suo· 3 shared E. Dann· 3 shared K. B. Meyer· 3 shared K. Polanski· 3 shared R. G. H. Lindeboom· 3 shared B. C. Kennedy· 2 shared

Activity by Year

2022-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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7 shared papersImmunology

M. R. Clatworthy

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1

S. Griffith, L. Muir, O. Suchanek, J. Hope, C. Pade, J. M. Gibbons, Z. K. Tuong, A. Fung, E. Touizer, C. Rees-Spear, A. Nans, C. Roustan, Y. Alguel, D. Fink, C. Orkin, , L. E. McCoy

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

bioRxiv · Feb 5, 2024 · PreprintMicrobiology

Temporal profiling of human lymphoid tissues reveals coordinated defence to viral challenge

M. L. Coates, N. Richoz, Z. K. Tuong, G. Bowyer, C. Y. C. Lee, J. R. Ferdinand, E. Gillman, M. McClure, R. Di Marco Barros, B. J. Stewart, M. R. Clatworthy

This study examines immune responses in human nasal-associated lymphoid tissue after SARS-CoV-2 infection, revealing coordinated defense mechanisms involving monocytes, macrophages, B cells, and T cells.

bioRxiv · Sep 15, 2023 · PreprintImmunology

Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

I. W. Dean, C. Y. Lee, Z. K. Tuong, Z. Li, C. A. Tibbitt, C. Willis, F. Gaspal, B. C. Kennedy, V. Matei-Rascu, R. Fiancette, C. Nordenvall, U. Lindforss, S. M. Baker, C. Stockmann, V. Sexl, , D. R. Withers

This study shows that conventional NK cells rapidly lose effector functions upon entering tumors and that IL-15:IL-15Ra complexes can restore their function and tissue-residency.

bioRxiv · Aug 10, 2023Immunology

Time-, tissue- and treatment-associated heterogeneity in tumour-residing migratory DCs

C. Y. Lee, B. C. Kennedy, N. Richoz, I. Dean, Z. K. Tuong, F. Gaspal, Z. Li, C. Willis, T. Hasegawa, S. K. Whiteside, D. A. Posner, G. Carlesso, S. A. Hammond, S. Dovedi, R. Roychoudhuri, , M. R. Clatworthy

This study identifies heterogeneous tumor-residing migratory dendritic cells (mRegDCs) that show distinct transcriptional and functional profiles, impacting anti-tumor immune responses.

bioRxiv · Jul 3, 2023Immunology

Early human lung immune cell development and its role in epithelial cell fate

J. L. Barnes, P. He, M. Yoshida, K. B. Worlock, R. G. H. Lindeboom, C. Suo, J. P. Pett, A. Wilbrey-Clark, E. Dann, L. Mamanova, L. Richardson, A. J. Oliver, A. L. Pennycuick, J. Allen-Hyttinen, I. T. Herczeg, , M. Z. Nikolic

The paper profiles lung immune cells during development using scRNAseq and identifies IL-1β's role in driving epithelial progenitor differentiation.

bioRxiv · Dec 13, 2022Immunology

Dandelion utilizes single cell adaptive immune receptor repertoire to explore lymphocyte developmental origins

C. Suo, K. Polanski, E. Dann, R. G. H. Lindeboom, R. Vilarrasa Blasi, R. Vento-Tormo, M. Haniffa, K. B. Meyer, L. M. Dratva, Z. K. Tuong, M. R. Clatworthy, S. Teichmann

Dandelion improves V(D)J analysis in scVDJ-seq data, enabling better lineage commitment predictions and insights into lymphocyte development.

bioRxiv · Nov 18, 2022 · PreprintImmunology

Spatial analysis of ligand-receptor interaction in skin cancer at genome-wide and single-cell resolution

M. Tran, S. Yoon, M. T. Siok, S. Andersen, P. Lam, B. Purdue, A. Raghubar, S. J. Hanson, K. Devitt, K. Jones, S. Walters, Z. K. Tuong, A. Kulasinghe, J. Monkman, P. H. Soyer, , Q. Nguyen

The paper develops a toolbox to study cancer-immune cell communication using multimodal data and a computational method called STRISH, validated on basal and squamous cell carcinomas.

Frontiers in Immunology · Jul 29, 2022Peer-reviewedCancer Biology

Mapping the developing human immune system across organs

C. Suo, E. Dann, I. Goh, L. Jardine, V. Kleshchevnikov, J.-E. Park, R. A. Botting, E. Stephenson, J. Engelbert, Z. K. Tuong, K. Polanski, N. Yayon, C. Xu, O. Suchanek, R. Elmentaite, , S. A. Teichmann

This study maps the developing human immune system across organs using single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics, revealing cross-gestation and cross-organ variability and identifying prenatal B1 cells and unconventional T cell origins.

bioRxiv · Jan 17, 2022Immunology

Obesity associated with attenuated tissue immune cell responses in COVID-19

S. A. Guo, G. S. Bowyer, J. R. Ferdinand, M. Maes, Z. K. Tuong, E. Gilman, M. Liao, R. G. H. Lindeboom, M. Yoshida, K. Worlock, H. Gopee, E. Stephenson, P. A. Lyons, K. G. C. Smith, M. Haniffa, , M. R. Clatworthy

The paper finds that obesity is associated with reduced immune and inflammatory responses in COVID-19 patients, including lower expression of IFN and IFNγ response genes in lung and blood cells.

bioRxiv · Jan 14, 2022 · PreprintImmunology