Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress
I. L. Shytaj, F. A. Procopio, M. Tarek, I. Carlon-Andres, H.-Y. Tang, A. R. Goldman, M. Munshi, M. Forcato, K. Leskov, F. Ye, B. Lucic, N. Cruz, A. Singh, S. Bicciato, S. Padilla-Parra, , A. Savarino
The paper shows that glycolysis downregulation is a hallmark of HIV-1 latency and that targeting antioxidant pathways can reactivate latent HIV-1.
bioRxiv · Dec 30, 2020Immunology