This study uses MYCroplanters to identify how host, microbiota, and pathogen factors interact to influence host health in an Arabidopsis-Pseudomonas system.

bioRxiv · Apr 26, 2024Ecology

Host subversion of bacterial metallophore usage drives copper intoxication

S. Hossain, J. R. Morey, S. L. Neville, K. Ganio, J. N. Radin, J. Norambuena, J. M. Boyd, C. A. McDevitt, T. E. Kehl-Fie

This paper shows that host use of metallophores to secrete copper intoxicates Staphylococcus aureus during infection.

bioRxiv · May 30, 2023Microbiology

Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B

T. S. Mehlman, J. T. Biel, S. M. Azeem, E. R. Nelson, S. Hossain, L. E. Dunnett, N. G. Paterson, A. Douangamath, R. Talon, D. Axford, H. Orins, F. von Delft, D. A. Keedy

This study compares cryo and room-temperature crystallography of PTP1B with small-molecule fragments, showing RT reveals different binding modes and conformational changes.

bioRxiv · Nov 2, 2022Biophysics

Oxygen depletion and nitric oxide stimulate type IV MSHA pilus retraction in Vibrio cholerae via activation of the phosphodiesterase CdpA

H. Q. Hughes, K. A. Floyd, S. Hossain, S. Anantharaman, D. T. Kysela, Y. Yu, M. P. Kappler, T. N. Dalia, R. C. Podicheti, D. B. Rusch, Y. V. Brun, S. C. Jacobson, J. B. McKinlay, F. H. Yildiz, E. M. Boon, A. B. Dalia

This study identifies oxygen depletion and nitric oxide as stimuli that trigger MSHA pilus retraction in V. cholerae via the phosphodiesterase CdpA.

bioRxiv · Apr 20, 2021Microbiology

Membrane insertion mechanism of the caveolae coat protein Cavin1

K.-c. Liu, H. Pace, E. Larsson, S. Hossain, A. Kabedev, A. Shukla, V. Jerschabek, J. Mohan, C. A. S. Bergstrom, M. Bally, C. Schwieger, M. Hubert, R. Lundmark

This study reveals how Cavin1 inserts into membranes through PI(4,5)P2-dependent adsorption and helix insertion, facilitated by flanking regions and co-assembly with Caveolin1.

bioRxiv · Mar 23, 2021Biochemistry

Highly pathogenic avian influenza (H5N1) landscape suitability varies by wetland habitats and the degree of interface between wild waterfowl and poultry in India

M. G. Walsh, S. M. Mor, S. Hossain

This study examines how wetland habitats and the wild waterfowl-poultry interface influence HPAI H5N1 epizootics in India, finding that landscape suitability varies with habitat type and interface degree.

bioRxiv · Sep 23, 2020Ecology

Repeated multi-domain, but not single-domain, cognitive training prevents cognitive decline and amyloid pathology found in the APPNL-G-F mouse model of Alzheimer disease

J. Mehla, S. H. Deibel, H. Karem, S. Hossain, S. G. Lacoursiere, R. J. Sutherland, R. J. McDonald, M. H. MOHAJERANI

The study shows that repeated multi-domain cognitive training, but not single-domain, improves cognitive function and reduces amyloid pathology in APPNL-G-F mice.

bioRxiv · Aug 24, 2020 · PreprintAnimal Behavior & Cognition

A preliminary ecological profile of Kyasanur Forest disease virus hosts among the mammalian wildlife of the Western Ghats, India

M. Walsh, S. Mor, H. Maity, S. Hossain

This study identifies ecological traits associated with Kyasanur Forest disease virus hosts in the Western Ghats, finding body mass and forest forage are linked to infection status.

bioRxiv · Jan 30, 2020Ecology