Author

K. Reue

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:metabolomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

L. Vergnes· 3 shared C. B. Wiese· 2 shared J. C. Link· 2 shared P. Zhang· 2 shared Y. Wang· 2 shared A. A. Vashisht· 1 shared A. Acevedo· 1 shared A. E. Jones· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPhysiology

L. Vergnes

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis

A. Acevedo, A. E. Jones, B. T. Danna, R. Turner, K. P. Montales, C. Beninca, K. Reue, O. S. Shirihai, L. Stiles, M. Wallace, Y. Wang, A. M. Bertholet, A. S. Divakaruni

The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.

bioRxiv · Aug 15, 2023 · PreprintBiochemistry

The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK

C. Chen, B. Lomenick, M. Chai, W. Huang, J. Chu, L. Vergnes, R. O. Johnson, A. A. Vashisht, R. M. Chin, M. M. Dix, G. Simon, X. Fu, J. C. Link, H. Hwang, X. Yin, , J. Huang

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

bioRxiv · Oct 10, 2022 · PreprintPhysiology

Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment

C. B. Wiese, Z. W. Agle, P. Zhang, K. Reue

This study investigates how chromosomal and gonadal sex affect lipid levels and hepatic gene expression in hypercholesterolemic mice under statin treatment.

bioRxiv · Aug 29, 2022Physiology

X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

P. Zhang, J. J. Munier, L. Vergnes, C. B. Wiese, J. C. Link, F. Abbasi, E. Ronquillo, A. Munoz, Y.-L. Kuang, M. Liu, G. Sanchez, A. Oni-Orisan, C. Iribarren, M. J. McPhaul, D. K. Nomura, , K. Reue

This study identifies X chromosome dosage and DHA reduction as drivers of statin-induced dysglycemia and mitochondrial dysfunction in females.

bioRxiv · Aug 29, 2022Physiology

The middle lipin (M-Lip) domain is a new dimeric protein fold that binds membranes

W. Gu, S. Gao, H. Wang, K. D. Fleming, R. M. Hoffmann, J. W. Yang, N. M. Patel, Y. M. Choi, J. E. Burke, K. Reue, M. V. Airola

The paper identifies the M-Lip domain as a novel dimeric protein fold that binds membranes and is essential for lipin function.

bioRxiv · Mar 19, 2021Biochemistry

Single Cell Analysis Reveals Immune Cell-Adipocyte Crosstalk Regulating the Transcription of Thermogenic Adipocytes

P. Rajbhandari, D. Arneson, A.-C. Feng, I. S. Ahn, G. Diamante, N. Zaghari, B. Thomas, L. Vergnes, S. Lee, K. Reue, S. Smale, X. Yang, P. Tontonoz

The paper identifies immune cell-adipocyte communication regulating thermogenic adipocyte transcription through single-cell analysis in mice.

bioRxiv · Jun 13, 2019Cell Biology