Author

A. M. Bertholet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Y. Kirichok· 2 shared A. Acevedo· 1 shared A. E. Jones· 1 shared A. L. Gunawan· 1 shared A. S. Divakaruni· 1 shared A. Stahl· 1 shared B. T. Danna· 1 shared B. Unger· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

Y. Kirichok

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis

A. Acevedo, A. E. Jones, B. T. Danna, R. Turner, K. P. Montales, C. Beninca, K. Reue, O. S. Shirihai, L. Stiles, M. Wallace, Y. Wang, A. M. Bertholet, A. S. Divakaruni

The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.

bioRxiv · Aug 15, 2023 · PreprintBiochemistry

Mitochondrial uncouplers impair human sperm motility without altering ATP content

W. M. Skinner, N. T. Petersen, B. Unger, S. Tang, E. Tabarsi, J. Lamm, L. Jalalian, J. Smith, A. M. Bertholet, K. Xu, Y. Kirichok, P. V. Lishko

This study shows mitochondrial uncouplers impair human sperm motility without reducing ATP content, suggesting ATP-independent mechanisms and potential contraceptive applications.

bioRxiv · Aug 4, 2022Cell Biology

Coenzyme Q regulates UCP1 expression and thermogenesis through the integrated stress responses

C.-F. Chang, A. L. Gunawan, P.-J. H. Zushin, G. A. Timblin, A. M. Bertholet, B. Wang, K. Saijo, Y. Kirichok, A. Stahl

This study shows that CoQ deficiency in BAT activates the ISR and suppresses UCP1, yet increases whole-body metabolic rates and reduces weight gain on HFD.

bioRxiv · Mar 18, 2022 · PreprintCell Biology