R. W. Stein

Lipid droplets protect human β cells from lipotoxic-induced stress and cell identity changes

This study shows that lipid droplets protect human β cells from lipotoxic stress by maintaining FFA homeostasis and preserving β cell identity.

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

In vivo studies of glucagon secretion by human islets transplanted in mice

This study uses CRISPR/Cas9 to create mice lacking human glucagon to study human islet glucagon secretion in vivo after transplantation.