Author

J. E. Manning Fox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 6 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 7 Organism:human· 7 Research Focus:differential expression· 5 Organism:mouse· 5 Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3

Frequent Co-Authors

P. E. MacDonald· 8 shared A. Bautista· 6 shared A. F. Spigelman· 6 shared N. Smith· 4 shared J. Lyon· 3 shared A. L. Gloyn· 2 shared H. Lin· 2 shared H. Sun· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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8 shared papersPhysiology

P. E. MacDonald

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Author profile →

9 papers

Recent·Most cited

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

K. K. Mattis, N. A. J. Krentz, C. Metzendorf, F. Abaitua, A. F. Spigelman, H. Sun, A. K. Rottner, A. Bautista, E. Mazzaferro, M. Perez-Alcantara, J. E. Manning Fox, J. M. Torres, A. Weslowska-Andersen, G. Z. Yu, A. Mahajan, , A. L. Gloyn

This study shows that loss of RREB1 in beta cells reduces insulin content and affects gene expression, linking RREB1 to diabetes risk through its role in beta cell function and development.

bioRxiv · Jun 4, 2022Physiology

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

T. A. Alghamdi, N. A. J. Krentz, N. Smith, A. F. Spigelman, V. Rajesh, A. Jha, M. Ferdaoussi, J. E. Manning Fox, H. Sun, Z. Sun, A. L. Gloyn, P. E. MacDonald

This study shows that Zmiz1 is essential for β-cell function and mass expansion in response to high fat feeding, linking its loss to diabetes.

bioRxiv · May 18, 2022Physiology

Impacts of the COVID-19 Pandemic on a Human Research Islet Program

T. J. Dafoe, T. dos Santos, A. F. Spigelman, J. Lyon, N. Smith, A. Bautista, P. E. MacDonald, J. E. Manning Fox

This study examines how the COVID-19 pandemic affected islet processing and distribution at a human research islet facility, finding reduced organ processing but maintained islet quality, though recipient feedback was poorer due to longer transit times.

bioRxiv · Dec 24, 2021Physiology

Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen

J. Bass, B. Marcheva, B. J. Weidemann, A. Taguchi, M. Perelis, K. M. Ramsey, M. V. Newman, Y. Kobayashi, C. Omura, J. E. Manning Fox, H. Lin, P. E. Macdonald

The paper identifies the P2Y1 purinergic receptor as a target to rescue circadian β-cell failure using a small-molecule screen and validates ivermectin as a glucose-dependent secretagogue.

bioRxiv · Nov 5, 2021Cell Biology

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

X.-Q. Dai, J. Camunas-Soler, L. J. Briant, T. dos Santos, A. F. Spigelman, E. M. Walker, R. Arrojo e Drigo, A. Bautista, R. C. Jones, J. Lyon, A. Nie, N. Smith, J. E. Manning Fox, S. K. Kim, P. Rorsman, , P. E. MacDonald

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

bioRxiv · Apr 8, 2021Cell Biology

β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice

H. Lin, N. Smith, A. F. Spigelman, K. Suzuki, M. Ferdaoussi, Y. Jin, A. Bautista, Y. W. Wang, J. E. Manning Fox, J. Buteau, P. E. MacDonald

This study shows that β-cell SENP1 improves insulin secretion in response to incretins and reduces oral glucose intolerance in high-fat-fed mice.

bioRxiv · Nov 30, 2020Physiology

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion

K. Viloria, D. Nasteska, L. J. B. Briant, S. Helsing, D. Larner, N. H. F. Fine, F. B. Ashford, G. da Silva Xavier, M. Jimenez Ramos, J. E. Manning Fox, P. E. MacDonald, I. Akerman, G. G. Lavery, C. Flaxman, N. G. Morgan, , D. J. Hodson

This study shows that vitamin D-binding protein (DBP) is essential for maintaining β-cell function and glucagon secretion, with reduced DBP expression observed in late-onset type 1 diabetes.

bioRxiv · Dec 19, 2019 · PreprintPhysiology

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific

R. Arrojo e Drigo, G. Erikson, S. Tyagi, J. Capitanio, J. Lyon, A. Spigelman, A. Bautista, J. E. Manning Fox, M. Shokhirev, P. MacDonald, M. Hetzer

This study analyzes age-related changes in human endocrine pancreatic cell types, finding sex-specific and cell-type-specific effects of aging on beta cell function and transcriptional profiles.

bioRxiv · Aug 8, 2019 · PreprintPhysiology

A glucose-dependent spatial patterning of exocytosis inhuman β-cells is disrupted in type 2 diabetes

J. Fu, J. M. Githaka, X. Dai, G. Plummer, K. Suzuki, A. F. Spigelman, A. Bautista, R. Kim, D. Greitzer-Antes, J. E. Manning Fox, H. Y. Gaisano, P. E. MacDonald

This study shows that glucose-dependent spatial organization of exocytosis in human β-cells is disrupted in type 2 diabetes.

bioRxiv · May 3, 2019Cell Biology