Author

A. Bautista

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 5 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Organism:human· 6 Approach:statistical model· 5 Research Focus:differential expression· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3

Frequent Co-Authors

P. E. MacDonald· 7 shared A. F. Spigelman· 6 shared J. E. Manning Fox· 6 shared N. Smith· 4 shared J. Lyon· 3 shared K. Suzuki· 3 shared X.-Q. Dai· 3 shared H. Lin· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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7 shared papersPhysiology

P. E. MacDonald

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

K. K. Mattis, N. A. J. Krentz, C. Metzendorf, F. Abaitua, A. F. Spigelman, H. Sun, A. K. Rottner, A. Bautista, E. Mazzaferro, M. Perez-Alcantara, J. E. Manning Fox, J. M. Torres, A. Weslowska-Andersen, G. Z. Yu, A. Mahajan, , A. L. Gloyn

This study shows that loss of RREB1 in beta cells reduces insulin content and affects gene expression, linking RREB1 to diabetes risk through its role in beta cell function and development.

bioRxiv · Jun 4, 2022Physiology

β-cell responses to high fat feeding: A role and mechanism for redox sensing by SENP1

H. Lin, K. Suzuki, N. Smith, X. Li, L. Nalbach, S. Fuentes, A. F. Spigelman, X.-Q. Dai, A. Bautista, M. Ferdaoussi, S. Aggarwal, A. R. Pepper, L. P. Roma, E. Ampofo, W.-h. Li, P. E. MacDonald

This study identifies SENP1's role in β-cell redox sensing during high-fat feeding, showing its requirement for enhanced exocytosis and glucose intolerance.

bioRxiv · Apr 5, 2022Cell Biology

Impacts of the COVID-19 Pandemic on a Human Research Islet Program

T. J. Dafoe, T. dos Santos, A. F. Spigelman, J. Lyon, N. Smith, A. Bautista, P. E. MacDonald, J. E. Manning Fox

This study examines how the COVID-19 pandemic affected islet processing and distribution at a human research islet facility, finding reduced organ processing but maintained islet quality, though recipient feedback was poorer due to longer transit times.

bioRxiv · Dec 24, 2021Physiology

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

X.-Q. Dai, J. Camunas-Soler, L. J. Briant, T. dos Santos, A. F. Spigelman, E. M. Walker, R. Arrojo e Drigo, A. Bautista, R. C. Jones, J. Lyon, A. Nie, N. Smith, J. E. Manning Fox, S. K. Kim, P. Rorsman, , P. E. MacDonald

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

bioRxiv · Apr 8, 2021Cell Biology

β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice

H. Lin, N. Smith, A. F. Spigelman, K. Suzuki, M. Ferdaoussi, Y. Jin, A. Bautista, Y. W. Wang, J. E. Manning Fox, J. Buteau, P. E. MacDonald

This study shows that β-cell SENP1 improves insulin secretion in response to incretins and reduces oral glucose intolerance in high-fat-fed mice.

bioRxiv · Nov 30, 2020Physiology

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

S. Skovso, E. Panzhinskiy, J. Kolic, H. H. Cen, D. A. Dionne, X.-Q. Dai, R. B. Sharma, L. Elghazi, C. E. Ellis, K. Faulkner, S. A. M. Marcil, P. Overby, N. Noursadeghi, D. Hutchinson, X. Hu, , J. D. Johnson

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

bioRxiv · Oct 15, 2020Physiology

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific

R. Arrojo e Drigo, G. Erikson, S. Tyagi, J. Capitanio, J. Lyon, A. Spigelman, A. Bautista, J. E. Manning Fox, M. Shokhirev, P. MacDonald, M. Hetzer

This study analyzes age-related changes in human endocrine pancreatic cell types, finding sex-specific and cell-type-specific effects of aging on beta cell function and transcriptional profiles.

bioRxiv · Aug 8, 2019 · PreprintPhysiology

A glucose-dependent spatial patterning of exocytosis inhuman β-cells is disrupted in type 2 diabetes

J. Fu, J. M. Githaka, X. Dai, G. Plummer, K. Suzuki, A. F. Spigelman, A. Bautista, R. Kim, D. Greitzer-Antes, J. E. Manning Fox, H. Y. Gaisano, P. E. MacDonald

This study shows that glucose-dependent spatial organization of exocytosis in human β-cells is disrupted in type 2 diabetes.

bioRxiv · May 3, 2019Cell Biology