A. F. Spigelman

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

This study shows that loss of RREB1 in beta cells reduces insulin content and affects gene expression, linking RREB1 to diabetes risk through its role in beta cell function and development.

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

This study shows that Zmiz1 is essential for β-cell function and mass expansion in response to high fat feeding, linking its loss to diabetes.

β-cell responses to high fat feeding: A role and mechanism for redox sensing by SENP1

This study identifies SENP1's role in β-cell redox sensing during high-fat feeding, showing its requirement for enhanced exocytosis and glucose intolerance.

Impacts of the COVID-19 Pandemic on a Human Research Islet Program

This study examines how the COVID-19 pandemic affected islet processing and distribution at a human research islet facility, finding reduced organ processing but maintained islet quality, though recipient feedback was poorer due to longer transit times.

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice

This study shows that β-cell SENP1 improves insulin secretion in response to incretins and reduces oral glucose intolerance in high-fat-fed mice.

A glucose-dependent spatial patterning of exocytosis inhuman β-cells is disrupted in type 2 diabetes

This study shows that glucose-dependent spatial organization of exocytosis in human β-cells is disrupted in type 2 diabetes.