Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD
Phoebe Ohene-Marfo, Sabira Mohammed, Chao Jiang, Shylesh Bhaskaran, Kara Kneuper, Satoshi Matsuzaki, Bo Hagy, Randal J. May, Constantin Georgescu, Megan John, Julianne N. Hoang, Kevin Pham, Albert Tran, Chinthalapally V. Rao, Tae Gyu Oh, , Sathyaseelan S. Deepa
This study shows that hepatocyte MLKL promotes obesity-driven MASLD-HCC through mitochondrial dysfunction and MFN2 suppression, independent of necroptosis.
Hepatology · Aug 4, 2026Peer-reviewedCancer Biology