Author

Sathyaseelan S. Deepa

OU Health Stephenson Cancer CenterORCID 0000-0002-3669-4820Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

Sabira MohammediD· 3 shared Albert Tran· 2 shared Chao JiangiD· 2 shared Constantin GeorgescuiD· 2 shared Courtney W. HoucheniD· 2 shared Jonathan D. WreniD· 2 shared Michael T KinteriD· 2 shared Phoebe Ohene-MarfoiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersCancer Biology

Sabira MohammedORCID

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3 papers

Recent·Most cited

Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD

Phoebe Ohene-Marfo, Sabira Mohammed, Chao Jiang, Shylesh Bhaskaran, Kara Kneuper, Satoshi Matsuzaki, Bo Hagy, Randal J. May, Constantin Georgescu, Megan John, Julianne N. Hoang, Kevin Pham, Albert Tran, Chinthalapally V. Rao, Tae Gyu Oh, , Sathyaseelan S. Deepa

This study shows that hepatocyte MLKL promotes obesity-driven MASLD-HCC through mitochondrial dysfunction and MFN2 suppression, independent of necroptosis.

Hepatology · Aug 4, 2026Peer-reviewedCancer Biology

A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran, Phoebe Ohene-Marfo, Kara F. Kneuper, Constantin Georgescu, Kamille Pitts, Albert Tran, Zongkai Peng, Amit Singh, Zhibo Yang, Tiangang Li, Bethany N. Hannafon, Courtney W. Houchen, , Sathyaseelan S. Deepa

This study shows that MLKL in hepatocytes promotes liver aging by inducing senescence and mitochondrial dysfunction without causing necroptosis.

Aging Cell · Jul 1, 2026Peer-reviewedCell Biology

Necroptosis increases with age in the brain and contributes to age-related neuroinflammation

Nidheesh Thadathil, Evan H. Nicklas, Sabira Mohammed, Tommy L. Lewis, Arlan G Richardson, Sathyaseelan S. Deepa

This study shows that necroptosis increases with age in the brain and contributes to age-related neuroinflammation in mice.

GeroScience · Sep 13, 2021Peer-reviewedNeuroscience