Selective persistence of HIV-1-infected T cell clones can occur through immune reprogramming driven by defective, transcriptionally active proviruses
Martin V. Hamann, Lisa Brauckmann, Christoph Schwarz, Michael Spohn, Ramon Stoeck, Sabrina M. Leddy, Julie Frouard, Maisha Adiba, Riekje Winzer, Sanamjeet Virdi, Adam T. Grundhoff, Cédric Feschotte, Frauke Muecksch, Nadia R. Roan, Eva Tolosa, U. Schiefer Lange
This study shows that defective HIV-1 proviruses can reprogram CD4+ T cells by altering BACH2 and STAT5B gene expression, leading to immune evasion and persistence in ART-treated individuals.
bioRxiv · Sep 22, 2025 · PreprintMicrobiology