Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling
Christina C. Ramelow, Eric B. Dammer, Hailian Xiao, Lihong Cheng, Prateek Kumar, Claudia Espinosa‐García, Maureen McGuirk Sampson, Dilpreet Kour, Ruth S. Nelson, Sneha Malepati, Rashmi Kumari, Wooyoung Eric Jang, QI GUO, Pritha Bagchi, Duc Minh Duong, , Srikant Rangaraju
This paper introduces SPARO, a method to simultaneously profile transcriptomes and proteomes of neural cell types, revealing mRNA-protein discordance patterns in astrocytes and neurons.
Nature Communications · Mar 31, 2026Peer-reviewedNeuroscience