Author

Ryan Willie

Princeton University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 9

Signature Assays, Organisms & Methods

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Organism:Drosophila· 7 Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Assay:spatial transcriptomics· 5 Approach:statistical model· 3 Research Focus:database / resource· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1

Frequent Co-Authors

H. Sebastian SeungiD· 9 shared Kyle Patrick Willie· 8 shared Szi-chieh YuiD· 8 shared Amy Robinson SterlingiD· 7 shared Ben Silverman· 7 shared Doug Bland· 7 shared Jay GageriD· 7 shared Mala MurthyiD· 7 shared

Activity by Year

2021-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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9 shared papersNeuroscience

H. Sebastian SeungORCID

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Author profile →

9 papers

Recent·Most cited

Uncovering Sex Differences in the Drosophila Ventral Nerve Cord Through Connectome Alignment

Arie Matsliah, Christopher K. Salmon, Alexander Shakeel Bates, Helen H. Yang, Daniel D. Lee, Lawrence K. Saul, Benjamin Silverman, Jay Gager, Szi-chieh Yu, Kyle Patrick Willie, Austin Burke, Ryan Willie, Doug Bland, Marissa Sorek, Celia David, , Mala Murthy

The paper automatically aligns Drosophila connectomes to classify neurons and identify sex-specific and sexually dimorphic cell types in the ventral nerve cord.

bioRxiv · Jun 27, 2026 · PreprintNeuroscience

Distributed control circuits across a brain-and-cord connectome

Alexander Shakeel Bates, Jasper S. Phelps, Minsu Kim, Helen H. Yang, Arie Matsliah, Zaki Ajabi, Eric Perlman, Kevin M. Delgado, Mohammed Abdal Monium Osman, Christopher K. Salmon, Jay Gager, Benjamin Silverman, Sophia Renauld, Farzaan Salman, Janki Patel, , Wei-Chung Allen Lee

The paper presents the first densely reconstructed adult fruit fly connectome integrating the brain and ventral nerve cord, revealing distributed control circuits involving local and long-range neural connections.

Lirias · Jun 8, 2026Peer-reviewedNeuroscience

New Synapse Detection in the Whole-Brain Connectome of Drosophila

Szi-chieh Yu, J. Alexander Bae, Arie Matsliah, Sven Dorkenwald, Jay Gager, James Hebditch, Ben Silverman, Kyle Patrick Willie, Ryan Willie, Austin Burke, Thomas Macrina, H. Sebastian Seung, Mala Murthy

The paper improves synapse detection in Drosophila brain connectomes using new neural networks, achieving better performance in challenging regions and improved neuron clustering.

bioRxiv · Jul 11, 2025 · PreprintNeuroscience

Functional connectomics spanning multiple areas of mouse visual cortex

J. Alexander Bae, Mahaly Baptiste, Maya R. Baptiste, Caitlyn A. Bishop, Ágnes L. Bodor, Derrick Brittain, Victoria Brooks, JoAnn Buchanan, Daniel J. Bumbarger, Manuel Castro, Brendan Celii, Erick Cobos, Forrest Collman, Nuno Maçarico da Costa, Bethanny P. Danskin, , Chi Zhang

The paper presents a functional connectomics dataset of mouse visual cortex, combining calcium imaging with EM reconstruction to study neural circuits and their connectivity.

Nature · Apr 9, 2025Peer-reviewedNeuroscience

Predicting modular functions and neural coding of behavior from a synaptic wiring diagram

Ashwin Vishwanathan, Alex Sood, Jingpeng Wu, Alexandro D. Ramirez, Runzhe Yang, Nico Kemnitz, Dodam Ih, Nicholas L. Turner, Kisuk Lee, Ignacio Tartavull, William Silversmith, Chris S. Jordan, Celia David, Doug Bland, Amy Robinson Sterling, , Sarah Williams

The paper uses a larval zebrafish connectome to predict neural coding of behavior and shows statistical matches with calcium imaging data.

Nature Neuroscience · Nov 22, 2024Peer-reviewedNeuroscience

Neuronal wiring diagram of an adult brain

Sven Dorkenwald, Arie Matsliah, Amy Robinson Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Albert Lin, Marta Costa, Katharina Eichler, Yijie Yin, William Silversmith, Casey M Schneider-Mizell, Chris S. Jordan, Derrick Brittain, Akhilesh Halageri, , Jansen Seguido

The paper presents the first neuronal wiring diagram of a whole adult Drosophila brain, revealing synaptic connections and circuit mechanisms underlying sensorimotor behaviors.

Nature · Oct 2, 2024Peer-reviewedNeuroscience

Neuronal "parts list" and wiring diagram for a visual system

Arie Matsliah, Szi-chieh Yu, Krzysztof Kruk, Doug Bland, Austin Burke, Jay Gager, James Hebditch, Ben Silverman, Kyle Patrick Willie, Ryan Willie, Marissa Sorek, Amy Robinson Sterling, Emil Kind, Dustin Garner, Gizem Sancer, , Gregory S.X.E. Jefferis

The paper completes the list of cell types in the Drosophila optic lobe and identifies connectivity rules, revealing new families and clusters related to visual functions.

Nature · Oct 2, 2024Peer-reviewedNeuroscience

FlyWire: Online community for whole-brain connectomics

Sven Dorkenwald, Claire E. McKellar, Thomas Macrina, Nico Kemnitz, Kisuk Lee, Ran Lu, Jingpeng Wu, Sergiy Popovych, Eric Mitchell, Barak Nehoran, Zhen Jia, J. Alexander Bae, Shang Mu, Dodam Ih, Manuel Castro, , H. Sebastian Seung

FlyWire enables collaborative proofreading of whole-brain connectomes through an online platform, demonstrating its utility in reconstructing and analyzing mechanosensory neuron circuits.

Nature Methods · Dec 23, 2021Peer-reviewedNeuroscience

3D reconstruction of cell nuclei in a full Drosophila brain

Shang Mu, Szi-chieh Yu, Nicholas L. Turner, Claire E. McKellar, Sven Dorkenwald, Forrest Collman, Selden Koolman, Merlin Moore, Sarah Morejohn, Ben Silverman, Kyle Patrick Willie, Ryan Willie, Doug Bland, Austin Burke, Zoe C. Ashwood, , H. Sebastian Seung

The paper reconstructs 3D cell nuclei in a Drosophila brain, identifying over 133,000 nuclei, mostly neurons, and highlights differences in nuclear size and cell density across brain regions.

bioRxiv · Nov 4, 2021 · PreprintNeuroscience