K. J. Verhey

KIF1C, an RNA transporting kinesin-3, undergoes liquid-liquid phase separation through its C-terminal disordered domain

This study shows KIF1C's C-terminal IDR drives LLPS, enabling RNA transport and revealing a new mode of motor-cargo interaction.

Autoinhibited kinesin-1 adopts a hierarchical folding pattern

This study determines the structure of autoinhibited kinesin-1 using XL-MS, EM, and AlphaFold, showing how light chains stabilize the inhibited state and how activation requires disrupting multiple domain interactions.

Differences in single-motor and multi-motor motility properties across the kinesin-6 family

The paper compares motility properties of kinesin-6 family members as single and multi-motor systems, finding differences in processivity and cargo transport capabilities.

A kinesin-1 variant reveals motor-induced microtubule damage in cells

This study shows a kinesin-1 variant causes microtubule damage in cells, leading to breakage and fragmentation, suggesting evolutionary pressure against such variants.

A Cytoskeletal Function for PBRM1 Reading Methylated Microtubules

This study identifies PBRM1 as the first cytoskeletal reader for SETD2-mediated -tubulin methylation, revealing a new role for PBRM1 in mitotic spindle organization and genomic stability.

SETD2 is an actin lysine methyltransferase

This study identifies SETD2 as an actin lysine methyltransferase that regulates actin polymerization and cell migration through methylation of the actin cytoskeleton.

Microtubule binding of the kinesin-4 KIF7 and its regulation by autoinhibition

This study shows that KIF7, an atypical kinesin, is autoinhibited to prevent microtubule binding and microtubule dynamics alteration in cells.

The Ciliary Lumen Accommodates Passive Diffusion and Vesicle Trafficking in Cytoplasmic-Ciliary Transport

The paper identifies two new transport pathways in primary cilia - passive diffusion and vesicle transport - using single molecule microscopy in live cells.

Acute inhibition of heterotrimeric kinesin-2 function reveals mechanisms of intraflagellar transport in mammalian cilia

This study inhibits kinesin-2 function to reveal its essential role in cilia assembly and function in mammalian cells.

Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts

The paper shows that autoinhibition of kinesin-1 is crucial for dendrite-specific Golgi outpost localization, preventing their mislocalization to axons.