Author

S. Forli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:statistical model· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Santos-Martins· 2 shared A. B. Ward· 1 shared A. H. Laustsen· 1 shared A. Ward· 1 shared A.-L. M. Fischer· 1 shared B. Cravatt· 1 shared B. E. Torbett· 1 shared B. F. Cravatt· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiophysics

D. Santos-Martins

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Assessing AF2's ability to predict structural ensembles of proteins

J. R. Riccabona, F. C. Spoendlin, A.-L. M. Fischer, J. R. Loeffler, P. K. Quoika, T. P. Jenkins, J. A. Ferguson, E. Smorodina, A. H. Laustsen, V. Greiff, S. Forli, A. Ward, C. Deane, M. L. Fernandez-Quintero

This study evaluates AF2's ability to predict protein structural ensembles by comparing its results with MD simulations and NMR data for four test proteins.

bioRxiv · Apr 16, 2024Biophysics

IP6 and PF74 affect HIV-1 Capsid Stability through Modulation of Hexamer-Hexamer Tilt Angle Preference

C. M. Garza, M. Holcomb, D. Santos-Martins, B. E. Torbett, S. Forli

This study uses atomistic simulations to show how IP6 and PF74 modulate HIV-1 capsid stability by altering hexamer-hexamer tilt angles, revealing distinct effects on structural flexibility.

bioRxiv · Mar 11, 2024Biophysics

A strain-specific inhibitor of receptor-bound HIV-1 targets a pocket near the fusion peptide and offers a template for drug design

G. Ozorowski, J. L. Torres, D. Santos-Martins, S. Forli, A. B. Ward

The paper identifies a strain-specific HIV-1 inhibitor targeting a pocket near the fusion peptide, demonstrating small molecules can disrupt viral fusion and offering a template for drug design.

bioRxiv · Jun 11, 2020Biophysics

An activity-guided map of electrophile-cysteine interactions in primary human immune cells

E. Vinogradova, D. Lazar, R. Suciu, Y. Wang, G. Bianco, Y. Yamashita, V. Crowley, D. Remillard, K. Lum, G. Simon, E. Kemper, M. Lazear, S. Yin, M. Blewett, M. Dix, , B. Cravatt

The paper maps electrophile-sensitive cysteines in primary human T cells and shows how electrophilic compounds affect T cell activation through cysteine modification.

bioRxiv · Oct 17, 2019 · PreprintImmunology

Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity

J. H. Xu, J. Eberhardt, B. Hill-Payne, G. E. Gonzalez-Paez, J. O. Castellon, B. F. Cravatt, S. Forli, D. W. Wolan, K. M. Backus

The paper uses X-ray crystallography and molecular modeling to study how a small-molecule inhibitor binds to and inhibits procaspase-8, revealing structural changes and key interactions.

bioRxiv · Aug 5, 2019Biochemistry