S. Harel

Elasticity of the HIV-1 Core Facilitates Nuclear Entry and Infection

This study shows that HIV-1 core elasticity is essential for nuclear entry and infection, with capsid-targeting drugs reducing elasticity and impairing infectivity.

When less is more - A fast TurboID KI approach for high sensitivity endogenous interactome mapping

The paper compares labelling enzymes for proximity labelling experiments using CRISPR-Cas9 knock-ins, showing TurboID's effectiveness in identifying interactors and cargo proteins.

ARF1 compartments direct cargo flow via maturation into recycling endosomes

The paper identifies two functionally distinct ARF1 compartments involved in post-Golgi sorting and endocytic recycling, challenging the classical vesicle shuttling model.

Nanoscale imaging reveals the mechanisms of ER-to-Golgi transport via a dynamic tubular-vesicular network

This study uses live-cell imaging to show ER-to-Golgi transport occurs via a dynamic ARF4 tubular-vesicular network connected to the ER and Golgi.

Characterization of individual HIV-1 budding event using ultra-fast atomic force microscopy reveals a multiplexed role for VPS4

This study uses ultra-fast atomic force microscopy to visualize HIV-1 budding events, revealing two kinetic pathways and a role for VPS4B in early budding stages.

HIV-1 uncoating occurs via a series of rapid biomechanical changes in the core related to individual stages of reverse transcription

This study uses atomic force microscopy to observe stiffness changes in HIV-1 cores during reverse transcription, linking mechanical spikes to specific stages of the process.