C. Hernandez

Heterologous Prime-Boost with Immunologically Orthogonal Protein Nanoparticles for Peptide Immunofocusing

This paper develops a vaccine strategy using immunologically orthogonal protein nanoparticles to focus antibody responses on a specific SARS-CoV-2 RBD epitope.

Programmable delivery of fluoxetine via wearable bioelectronics for wound healing in vivo

This paper introduces a wearable bioelectronic bandage that delivers fluoxetine on-demand to wounds, reducing inflammation and accelerating healing in mice.

Interferon epsilon restricts Zika virus infection in the female reproductive tract

This study shows that IFNε protects against vaginal ZIKV infection in mice by maintaining epithelial integrity and is effective even without IFNAR1 signaling.

New insights from short and long reads sequencing to explore cytochrome b variants of Plasmopara viticola populations collected in vineyard and related to resistance to complex III inhibitors

The paper uses short and long-read sequencing to identify cytochrome b variants in Plasmopara viticola populations associated with resistance to fungicides, showing long reads' ability to detect complex variants.

Conventional polymers may unintentionally refill in vivo with unassociated drugs

This paper investigates the refilling capacity of PLGA implants, finding that even unmodified PLGA can refill with unassociated drugs, contrary to expectations.

Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation

This study shows that redox regulation of PTPN22 via cysteine 129 affects T cell-dependent autoimmune inflammation severity in mice.

A poxvirus decapping enzyme localizes to mitochondria to regulate RNA metabolism and translation, and promote viral replication

This study identifies vaccinia virus D10 as a mitochondria-localized decapping enzyme that promotes viral replication by preferentially targeting cellular mRNAs for decapping and enhancing viral mRNA translation.

Implementing QR Codes in Academia to Improve Sample Tracking, Data Accessibility, and Traceability in Multicampus Interdisciplinary Collaborations

This paper introduces a QR code tracking system to improve sample and data traceability across multicampus interdisciplinary collaborations, enhancing efficiency and reducing resource waste.

Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex

This paper shows that SARS-CoV-2 RdRp undergoes backtracking, which may aid proofreading and antiviral resistance.

HUMAN PANCREATIC CANCER CELLS UNDERGO PROFOUND METABOLIC REPROGRAMMING TOWARDS CELLULAR STEMNESS AS ADAPTATION TO INHIBITION OF THE AKT PATHWAY

This study shows that pancreatic cancer cells adapt to AKT pathway inhibition by reprogramming metabolism and acquiring stemness traits, which can be targeted with combined therapy.

Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis and beta-cell mass decline in mouse models of type 1 diabetes

An altered metabolism could contribute to the low activation of neonatal CD8+T cells

The paper investigates how altered metabolism and ROS levels affect neonatal CD8+T cell activation, showing that lower ROS status explains reduced activation rates compared to adult cells.

Adaptive and maladaptive genetic diversity in small populations; insights from the Brook Charr (Salvelinus fontinalis) case study

The paper examines genetic diversity in Brook Charr populations, finding increased deleterious mutations in isolated populations and environmental associations with adaptive loci.

Bubble Trouble: Conquering Microbubble Limitations in Contrast Enhanced Ultrasound Imaging by Nature-Inspired Ultrastable Echogenic Nanobubbles

This paper develops ultrastable nanobubbles for ultrasound imaging by engineering a dual-layer shell inspired by bacterial cell envelopes, improving in vivo stability and signal persistence.

Mechanical stress compromises multicomponent efflux complexes in bacteria

The paper shows mechanical stress, specifically shear stress, disrupts the CusCBA efflux complex in E. coli, increasing metal toxicity susceptibility.

The Microbial Metagenome and Tissue Composition in Mice with Microbiome-Induced Reductions in Bone Strength

This study links microbiome-induced changes in vitamin K synthesis to reduced bone strength in mice through metagenomic analysis.

Bone-Inspired Microarchitectured Materials with Enhanced Fatigue Life

This study investigates how microarchitecture affects fatigue life in cancellous bone and synthetic materials, finding that transverse struts significantly enhance fatigue life despite minimal impact on stiffness.