N. Okada

Live-cell imaging under centrifugation characterized the cellular force for nuclear centration in the Caenorhabditis elegans embryo

The paper measures cellular forces for nuclear centration in C. elegans embryos using centrifugation and microscopy, finding forces increase linearly with distance and friction is reduced in microtubule mutants.

Myeloid-derived suppressor cells exacerbate poly(I:C)-induced lung inflammation in mice with renal injury and older mice

This study shows that increased myeloid-derived suppressor cells (MDSCs) in mice with renal injury or aging worsen lung inflammation caused by viral pneumonia.

HDAC1-3 inhibition reduces CCR2 expression and immunosuppressive function of myeloid-derived suppressor cells

This study shows HDAC1-3 inhibitors reduce CCR2 expression and immunosuppressive function of MDSCs, enhancing antitumor effects in HCC.

Fission yeast Dis1 is an unconventional TOG/XMAP215 that induces microtubule catastrophe to drive chromosome pulling

This study shows that Dis1 in fission yeast promotes microtubule catastrophe at kinetochores to drive chromosome movement during cell division, differing from other TOG/XMAP215 orthologs.

NFYA promotes the anti-tumor effects of gluconeogenesis in hepatocellular carcinoma through the regulation of PCK1 expression

This study shows that NFYAv2 promotes anti-tumor effects in HCC by upregulating PCK1, leading to increased ROS and energy crisis, and suggests it as a potential therapeutic target.

NFYA promotes the malignant behavior of triple-negative breast cancer through the regulation of lipid metabolism

The paper shows NFYAv1 promotes TNBC malignancy by enhancing lipid metabolism, and targeting this axis could be a therapeutic strategy.

Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking

The paper uses time-lapse single-cell transcriptomics to show histone H3 gene expression fluctuation is crucial for breaking dormancy in fission yeast spores.

CLASP2 lattice-binding near microtubule plus ends stabilizes kinetochore attachments

This study identifies CLASP2's role in stabilizing kinetochore microtubule attachments through lattice-binding near microtubule plus ends, ensuring accurate chromosome segregation.

Development of the Brief Personal Values Inventory for sense of values in the Japanese general population

The paper develops a shorter questionnaire, BPVI, to assess sense of values in Japanese adults, showing it aligns with Schwartz's value theory and is suitable for comparing values across age groups.